摘要
目的对中药广藿香的活性化合物进行网络药理学研究,探索其抗炎作用的分子作用机制。方法通过TcmSP、TCM Database@Taiwan和PharmMapper等数据库筛选广藿香活性成分及其作用靶点,筛选结果与Therapeutic Target Database和DrugBank数据库中得到的炎症靶点相比较,总结筛选出广藿香活性成分抗炎作用的潜在靶点。采用Divide软件对靶点进行基因注释,利用Cytoscape软件构建广藿香抗炎多成分-多靶点-多通路作用网络并分析。结果网络分析表明广藿香17个活性成分作用于21个炎症靶点,涉及11条代谢通路,参与信号转导、蛋白水解和炎症反应等相关生物过程。结论广藿香抗炎作用体现了中药多成分-多靶点-多通路的作用特点,该研究为深入阐述广藿香抗炎作用机制提供科学依据。
Objective:To explore the molecular mechanism for Pogostemon cablin(Blanco)Benth intervening anti-inflammatory effect based on computing network pharmacological studies.Method:The active components and their action targets of patchouli were screened by TcmSP,TCMDatabase@Taiwan and PharmMapper databases.The screening results were compared with the inflammatory targets obtained from TherapeuticTargetDatabase and DrugBank,and the potential anti-inflammatory targets of the active components of patchouli were summarized and screened.The gene of the target was annotated by Divide software,and the anti-inflammatory multi-component-multi-target-multi-pathway action network of patchouli was constructed and analyzed by Cytoscape software.Result:The network analysis indicates that the 17 active ingredients of Guanghuoxiang through 21 targets taffected 11 pathways participating in the Signal transduction,proteolysis,and inflammatory response relevant biological processes.Conclusion:The anti-inflammatory effect of Guanghuoxiang reflects the features of traditional Chinese medicine in multi-components,multi-targets and multi-pathways.This research provides a scientific basis for elucidation of the anti-inflammatory pharmacological mechanism of Guanghuoxiang.
作者
孙适远
牟立婷
宗希明
张舒婷
任恒鑫
Sun Shiyuan;Mu Liting;Zhong Ximing;Zhang Shuting;Ren Hengxin(Pharmaceutical College of Jiamusi University,Jiamusi 154007;College of Materials Science and Engineering,Jiamusi University,Jiamusi 154007,China)
出处
《广东化工》
CAS
2020年第2期14-16,23,共4页
Guangdong Chemical Industry
基金
黑龙江省教育厅科学技术研究项目(12541809)
佳木斯大学科学技术研究项目(13Z1201563)
关键词
广藿香
网络药理学
炎症
反向分子对接
Pogostemon cablin(Blanco)Benth
network pharmacology
inflammation
reverse docking
