摘要
宫颈癌是最常见的妇科恶性肿瘤,在发展中国家,宫颈癌的发病率与死亡率常年居高不下,虽然关于宫颈癌的研究已广泛开展,但其具体发生机制及协同因素至今尚未阐明。近年来,基因突变与宫颈癌的关系逐渐受到重视。众多研究表明,癌基因、抑癌基因及相关调节基因的改变与宫颈癌发生及病情的进展密切相关。随着基因组测序技术在恶性肿瘤中的应用,更多基因的突变情况在宫颈癌中被发现,其中显著突变基因的确定可帮助进一步锁定恶性肿瘤驱动基因,故显著突变基因可能是发现恶性肿瘤内在机制的关键所在。对宫颈癌中新发现的显著突变基因ErbB-2受体酪氨酸激酶3(ErbB-3)、人类白细胞抗原A(HLA-A)、半胱氨酸天冬氨酸特异性蛋白酶8(CASP8)、转化生长因子βⅡ型受体(TGFBR2)的研究现状进行综述,可能为宫颈癌的机制研究、诊断及靶向治疗提供新的思路。
Cervical cancer is the most common gynecological malignant tumor. In developing countries, the incidence and mortality of cervical cancer are always high. Although the research on cervical cancer has been widely carried out, its specific mechanism and synergistic factors have not yet been elucidated. In recent years, more and more attention has been paid to the relationship between gene mutations and cervical cancer. Numerous studies have shown that changes in oncogenes, tumor suppressor genes and related regulatory genes are closely related to the development of cervical cancer and the progression of the disease. With the application of genome sequencing technology in cancer, more gene mutations are found in cervical cancer, and the identification of significant mutations can help further lock cancer-driven genes, so significant mutations may be the key to discover the underlying mechanisms of cancer. This overview of recent research status of the newly discovered significant mutations Erb B-3, HLA-A,CASP8 and TGFBR2 in cervical cancer may provide new ideas for the mechanism research, diagnosis and targeted therapy of cervical cancer.
作者
傅培强
王伟
郝敏
FU Pei-qiang;WANG wei;HAO Min(Department of Obstetrics and Gynecology,Second Affiliated Hospital of Shanxi Medical University,Taiyuan 030000,China)
出处
《国际妇产科学杂志》
CAS
2020年第1期10-14,共5页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金（81972452）
国家卫计委公益性行业科研专项（201402010）
山西省重点研发计划项目（201803D31121）
山西省卫生计生委科研课题（2018GW04）
