摘要
目的:探究解郁熄风汤联合穴位注射治疗不寐证患者的临床疗效及对睡眠结构的影响。方法:选取2017年2月至2019年1月杨浦区中医医院收治的不寐证患者114例作为研究对象,随机分为对照组和观察组,每组57例。予以对照组患者解郁熄风汤治疗,予以观察组患者解郁熄风汤联合穴位注射治疗,比较2组患者临床治疗效果、治疗前后患者证候(入睡困难、浅睡易醒、夜寐早醒、烦躁易怒、乏力、口苦口干、胁痛)积分、患者睡眠结构各时期(入睡期、浅睡期、熟睡期、深睡期、快速动眼期)睡眠质量评分、患者匹兹堡睡眠质量评分(PSQI)及治疗前后2组患者白细胞介素(IL-1β)水平、不良反应情况及治疗满意率。结果:观察组患者治疗有效率(98.25%)高于对照组(87.72%)(P<0.05);治疗前,2组患者入睡困难、浅睡易醒、夜寐早醒、烦躁易怒、乏力、口苦口干、胁痛等中医证候积分比较,差异无统计学意义(P>0.05),治疗后2组患者中医证候积分均改善,观察组优于对照组(P<0.05);治疗前,2组患者睡眠结构各时期(入睡期、浅睡期、熟睡期、深睡期、快速动眼期)睡眠质量评分及PSQI评分比较,差异均无统计学意义(P>0.05),治疗后2组患者各项评分均有改善,观察组优于对照组(P<0.05);治疗前,2组患者IL-1β水平比较,差异无统计学意义(P>0.05),治疗后各组患者IL-1β水平均有改善,观察组优于对照组(P<0.05)。2组治疗过程中均未见不良反应出现;观察组治疗满意率(98.25%)高于对照组(82.46%)(P<0.05)。结论:解郁熄风汤联合穴位注射治疗不寐证效果明显,可较好改善患者症状,提升患者睡眠质量,降低炎性因子水平,而且不良反应少,安全性高,患者满意率高,值得推广与应用。
Objective:To explore the effects of Jieyu Xifeng Decoction combined with acupoint injection on the clinical efficacy and sleep structure of patients with insomnia.Methods:A total of 114 cases of insomnia patients in Yangpu District Hospital of Traditional Chinese Medicine from February 2017 to January 2019 were included in this study.According to the treatment methods,the patients were divided into a control group and an observation group by adopting the random number table method.The control group(57 cases)was treated with Jieyu Xifeng Decoction,and the observation group(57 cases)was treated with Jieyu Xifeng Decoction combined with acupoint injection.The clinical treatment effects,patients with syndrome before and after the treatment(difficulty falling asleep,shallow,night sleep soundly sleeping easy waking early awakening,irritability,fatigue,dry mouth,bitter mouth,hypochondriac pain)integral,sleep structure in each period in patients with stage(sleep,light sleep stage,sleeping,deep sleep and rem sleep)in patients with sleep quality score,Pittsburgh sleep quality score(PSQI)and the level of interleukin(IL-1β),adverse reactions and treatment satisfaction of 2 groups of patients before and after the treatment were compared.Results:The effective rate of treatment in the observation group(98.25%)was higher than that in the control group(87.72%)(P<0.05).Before treatment,the TCM syndrome scores of difficulty in falling asleep,light sleep easy to wake up,night sleep early wake up,irritability,fatigue,mouth pain,dry mouth,side pain of the 2 groups were similar(P>0.05).After treatment,the syndrome points were improved,and the observation group was better than the control group(P<0.05);Before treatment,the sleep quality score and PSQI score of patients in the 2 groups at different stages of sleep structure(sleep stage,light sleep stage,deep sleep stage,rapid eye movement stage)were similar(P>0.05),and the scores were improved after treatment.The observation group was superior to the control group(P<0.05).Before treatment,the levels of IL-1βwere similar in the 2 groups(P>0.05),and the levels of IL-1βwere improved in each group after treatment(P<0.05).The observation group was superior to the control group(P<0.05).No adverse reactions were found in the 2 groups during the treatment,and the adverse reaction rate was 0.00%(P>0.05).The treatment satisfaction rate(98.25%)in the observation group was higher than that in the control group(82.46%)(P<0.05).Conclusion:Jieyu Xifeng Decoction combined with acupoint injection for the treatment of insomnia has a good effect,which can better improve the symptoms of patients,improve the sleep quality of patients,improve the level of inflammatory factors,with few adverse reactions,high safety,high satisfaction rate of patients,and it is worthy of promotion and application.
作者
王春燕
程学莲
苏云婷
冯小红
张雯静
Wang Chunyan;Cheng Xuelian;Su Yunting;Feng Xiaohong;Zhang Wenjing(Yangpu District Hospital of Traditional Chinese Medicine,Shanghai 3200090,China)
出处
《世界中医药》
CAS
2019年第12期3354-3358,共5页
World Chinese Medicine
基金
上海市杨浦区科研计划项目(yp17zm14)
关键词
不寐证
解郁熄风汤
穴位注射
疗效
睡眠结构
不良反应
Insomnia syndrome
Jieyu Xiefeng Decoction
Acupoint injection
Curative effect
Sleep structure
Adverse reactions
