摘要
目的研究糖足方联合负压封闭引流术(VSD)治疗糖尿病足溃疡创面的临床疗效。方法选取2019年1月—2019年8月期间治疗的糖尿病足(DF)患者50例作为研究对象,按随机数字表法分为观察组和对照组,每组25例,给予对照组常规治疗,并在麻醉清创后行VSD;观察组在对照组的基础上服用自拟的中药汤方糖足方配合治疗,比较两组患者治疗前后溃疡面积、溃疡深度、新鲜肉芽和分泌物渗出评分及视觉模拟评分(VAS),比较两组治疗前后白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、白细胞介素8(IL-8)、C反应蛋白(CRP)、糖化血红蛋白(HbA1c)水平。结果观察组治疗后创面面积、创面深度、肉芽情况及渗出情况计分均明显低于治疗前及对照组治疗后,差异有统计学意义(P<0.05)。观察组治疗1、2、3周后VAS评分均显著低于治疗前及对照组治疗1、2、3周后,差异有统计学意义(P<0.05)。观察组治疗后的IL-1β、IL-6、HBA1c、CRP均明显低于治疗前及对照组治疗后,差异有统计学意义(P<0.05)。两组治疗后IL-8与治疗前比较明显降低,差异有统计学意义(P<0.05)。结论糖足方联合VSD治疗DF患者溃疡创面疗效较好,且能缓解患者疼痛,有较高临床价值。
Objective To study the clinical efficacy of Tangzu Prescription combined with vacuum sealing drainage(VSD)in treating diabetic foot ulcer wounds.Methods 50 patients with diabetic foot(DF)treated in our hospital from January,2019 to August,2019 were selected as the study subjects.They were randomly divided into the observation group and the control group by using random number table,with 25 patients in each group.The control group was given routine treatment and VSD was performed after debridement of anesthesia.On the basis of the control group,the observation group was treated with self-formulated Tangzu Prescription.The ulcer area,ulcer depth,fresh granulation and secretion exudation score and visual analogue score(VAS)before and after treatment were compared between the two groups.The levels of interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-8(IL-8),C-reactive protein(CRP)and glycosylated hemoglobin(HbA1c)in both groups were compared before and after treatment.Results The scores of wound area,wound depth,granulation and exudation in the observation group after treatment were significantly lower than those before treatment and after treatment in the control group(P<0.05).The VAS scores of the observation group after 1,2 and 3 weeks of treatment were significantly lower than those before treatment and after 1,2 and 3 weeks of treatment in the control group,with significance(P<0.05).The levels of IL-1β,IL-6,HBA1c and CRP in the observation group after treatment were significantly lower than those before treatment and after treatment in the control group(P<0.05).After treatment,IL-8 in the two groups was significantly lower than that before treatment(P<0.05).Conclusion Tangzu Prescription combined with VSD has better curative effect on ulcer wound and relieving pain of DF patient with a high clinical value.
作者
袁佳沁
朱美冬
宋福晨
李琪
张磊
YUAN Jia-qin;ZHU Mei-dong;SONG Fu-chen;LI Qi;ZHANG Lei(Department of Vascular Surgery,Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437)
出处
《世界中西医结合杂志》
2020年第1期139-142,共4页
World Journal of Integrated Traditional and Western Medicine
基金
上海市中医药三年行动计划[2018-2020]项目[基于“湿郁筋损”理论的糖尿病足坏疽临床研究(ZY[2018-2020]-CCCX-4005)]子任务
关键词
糖足方
负压封闭引流术
糖尿病足
tangzu prescription
vacuum sealing drainage
diabetic foot
