摘要
目的:探讨老年焦虑症伴睡眠障碍患者应用米氮平结合重复经颅磁刺激(rTMS)治疗效果。方法:选取本院于2018年1月-2019年2月收治的80例老年焦虑症伴睡眠障碍患者,按照随机数字表法分为对照组与研究组,各40例。对照组予以米氮平治疗,研究组予以米氮平结合rTMS治疗。比较两组临床疗效、焦虑自评量表(SAS)、汉密尔顿焦虑量表(HAMA)、匹兹堡睡眠质量量表(PSQI)评分以及生活质量评分。结果:研究组治疗总有效率为92.50%高于对照组的70.00%(P<0.05)。干预前,两组HAMA与SAS评分比较,差异均无统计学意义(P>0.05)。干预后,两组HAMA与SAS评分均明显低于干预前,且研究组HAMA与SAS评分低于对照组(P<0.05)。干预前,两组PSQI各维度评分比较,差异均无统计学意义(P>0.05)。干预后,两组PSQI各维度评分均明显低于干预前,且研究组PSQI各维度评分均低于对照组(P<0.05)。干预前,两组生活质量各维度评分比较,差异均无统计学意义(P>0.05)。干预后,两组生活质量各维度评分均明显高于干预前,且研究组生活质量各维度评分高于对照组(P<0.05)。结论:米氮平结合rTMS治疗可明显改善老年焦虑症伴睡眠障碍患者焦虑情况以及睡眠质量,提高生活质量。
Objective: To explore the clinical effect of Mirtazapine combined with repetitive transcranial magnetic stimulation(rTMS) in the treatment of elderly anxiety disorders with sleep disorders. Method: A total of 80 elderly patients with anxiety disorders and sleep disorders admitted to our hospital from January 2018 to February 2019 were selected and divided into control group and study group according to the random number table method, 40 cases in each group. The control group was treated with Mirtazapine, and the study group was treated with Mirtazapine combined with rTMS. The clinical efficacy, self-rating anxiety scale(SAS), Hamilton anxiety scale(HAMA), Pittsburgh sleep quality inventory(PSQI) and quality of life scores were compared between the two groups. Result: The total effective rate of treatment in the study group was 92.50% higher than 70.00% in the control group(P<0.05). There were no significant differences in HAMA and SAS scores between the two groups before intervention(P>0.05). After intervention, HAMA and SAS scores of the two groups were significantly lower than those before intervention, and HAMA and SAS scores of the study group were lower than those in the control group(P<0.05). There were no significant differences in all PSQI scores between the two groups before intervention(P>0.05). After intervention, all PSQI scores of the two groups were significantly lower than those before intervention, and all PSQI scores of the study group were lower than those in the control group(P<0.05). There were no significant differences in the all scores of QOL between the two groups before intervention(P>0.05). After intervention, the all scores of QOL in the two groups were significantly higher than those before intervention, the all scores of QOL in the study group were higher than those in the control group(P<0.05). Conclusion: Mirtazapine combined with rTMS in the treatment of elderly anxiety patients with sleep disorders can significantly improve anxiety and sleep quality, improve the quality of life.
作者
陈晓莹
尹祚平
朱列和
陈康
CHEN Xiaoying;YIN Zuoping;ZHU Liehe;CHEN Kang(Mental Sleep Clinic of Huizhou Central People’s Hospital,Huizhou 516001,China)
出处
《中国医学创新》
CAS
2019年第34期27-31,共5页
Medical Innovation of China
关键词
焦虑症
睡眠障碍
米氮平
重复经颅磁刺激
睡眠质量
Anxiety disorder
Sleep disorder
Mirtazapine
Repeated transcranial magnetic stimulation
Sleep quality
