摘要
目的:探讨卡前列素氨丁三醇联合缩宫素对双胎妊娠剖宫产预防产后出血及对凝血功能的影响。方法:选取2014年12月-2018年12月本院接诊的44例行剖宫产的双胎妊娠产妇作为研究对象,按随机数字表法分为观察组和对照组,各22例。在胎儿娩出后,对照组给予缩宫素治疗,观察组在对照组基础上联合卡前列氨丁三醇治疗。比较两组产后不同时间出血量、宫缩持续时间、宫底下降速度、恶露持续时间、应激指标、凝血功能和不良反应。结果:观察组术中、术后2 h及术后2~24 h出血量均明显低于对照组(P<0.05)。观察组宫缩持续时间与宫底下降速度均明显高于对照组,恶露持续时间明显短于对照组(P<0.05)。观察组手术结束与术后24 h时,丙二醛(MDA)水平均明显低于对照组,而超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-px)、过氧化氢酶(CAT)水平均明显高于对照组(P<0.05)。观察组手术结束与术后24 h时,纤维蛋白原(FBI)、凝血酶原时间(PT)、D-二聚体(D-D)水平均明显低于对照组(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:卡前列素氨丁三醇联合缩宫素在双胎妊娠剖宫产预防产后出血效果显著,可减轻围术期应激反应,改善凝血功能且用药安全。可于临床推广。
Objective: To study the effect of Carboprost Tromethamine combined with Oxytocin on prevention of postpartum hemorrhage and coagulation function in twin pregnancies after cesarean section. Method: A total of 44 twin pregnant women underwent cesarean section from December 2014 to December 2018 in our hospital were selected as research objects. According to the random number table method, they were divided into observation group and control group, 22 cases in each group. After the birth of the fetus, the control group was treated with Oxytocin, while the observation group was treated with Carboprost Tromethamine on the basis of the control group. The different postpartum time blood loss, duration of contractions, descending rate of uterine fundus, duration of lochia, stress indicators, coagulation function and adverse reactions were compared between the two groups. Result: The blood loss intraoperative, postoperative 2 and 2-24 h in the observation group were significantly lower than those in the control group(P<0.05). The duration of contractions and descending rate of uterine fundus in the observation group were significantly higher than those in the control group, and the duration of lochia was significantly lower than that in the control group(P<0.05). At the end of the operation and 24 h after the operation, malondialdehyde(MDA) levels in the observation group were significantly lower than those in the control group, while superoxide dismutase(SOD), glutathione peroxidase(GSH-px) and catalase(CAT) levels were significantly higher than those in the control group(P<0.05). At the end of the operation and 24 h after the operation, the fibrinogen(FBI), prothrombin time(PT) and D-dimer(D-D) levels in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in the incidence of complications between the two groups(P>0.05). Conclusion: The effect of Carboprost Tromethamine combined with Oxytocin on preventing postpartum hemorrhage in cesarean section of twin pregnancy is significant. It can reduce the perioperative stress response, improve the coagulation function and be safe to use, which can be popularized in clinic.
作者
任春霞
张青霞
张少玉
REN Chunxia;ZHANG Qingxia;ZHANG Shaoyu(Fuding Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuding 355200,China)
出处
《中国医学创新》
CAS
2019年第34期67-70,共4页
Medical Innovation of China
关键词
卡前列素氨丁三醇
剖宫产
产后出血
凝血功能
Carboprost Tromethamine
Cesarean section
Postpartum hemorrhage
Coagulation function
