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慢性乙型肝炎与肝硬化患者凝血功能及血小板参数指标的变化及临床意义 被引量:10

Changes and Clinical Significance of Coagulation Function and Platelet Parameters Patients with Chronic Hepatitis B and Cirrhosis
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摘要 目的:探讨慢性乙型肝炎与肝硬化患者凝血功能及血小板参数指标的变化及临床意义。方法:选取2017年1月-2019年1月本院收治的肝病患者140例,依据是否进展至肝硬化,分为慢性乙型肝炎组72例和肝硬化组68例;另选择同期健康体检者80例为对照组。比较三组及肝硬化不同肝功能分级患者的凝血功能指标(PT、APTT、TT、FIB、DD)和血小板参数指标(PLT、PCT、MPV、PDW)。结果:慢性乙型肝炎组和肝硬化组的PT、APTT、TT、DD、MPV、PDW均显著高于对照组,且肝硬化组均高于慢性乙型肝炎组,差异均有统计学意义(P<0.05);慢性乙型肝炎组和肝硬化组的FIB、PLT、PCT均显著低于对照组,且肝硬化组均低于慢性乙型肝炎组,差异均有统计学意义(P<0.05)。随着肝功能分级的增加,PT、APTT、TT、DD、MPV、PDW均显著升高,FIB、PLT、PCT均显著下降,差异均有统计学意义(P<0.05)。结论:慢性乙型肝炎和肝硬化患者均有明显的凝血功能障碍和血小板参数异常,对疾病的诊断、预后具有十分重要的临床意义和参考价值。 Objective:To explore the changes and clinical significance of coagulation function and platelet parameters in patients with chronic hepatitis B and cirrhosis.Method:A total 140 patients with liver disease admitted to our hospital from January 2017 to January 2019 were selected,according to the progression to cirrhosis,they were divided into chronic hepatitis B group(n=72)and cirrhosis group(n=68),and 80 healthy people who underwent physical examination in the same period were selected as the control group.The coagulation indexes(PT,APTT,TT,FIB,DD)and platelet parameters(PLT,PCT,MPV,PDW)in the three groups and patients with different liver function grades of cirrhosis were compared.Result:The PT,APTT,TT,DD,MPV and PDW in chronic hepatitis B group and cirrhosis group were significantly higher than those in the control group,the cirrhosis group were higher than those of the chronic hepatitis B group,the differences were statistically significant(P<0.05).The FIB,PLT and PCT in chronic hepatitis B group and cirrhosis group were significantly lower than those in control group,the cirrhosis group were lower than those of the chronic hepatitis B group,the differences were statistically significant(P<0.05).With the increase of liver function grade,PT,APTT,TT,DD,MPV,PDW increased significantly,FIB,PLT,PCT decreased significantly,the differences were statistically significant(P<0.05).Conclusion:Patients with chronic hepatitis B and cirrhosis have significant coagulation dysfunction and abnormal platelet parameters,which is of great clinical significance and reference value for the diagnosis and prognosis of the disease.
作者 李志英 刘申颖 欧阳卫泽 雷霞 LI Zhiying;LIU Shenying;OUYANG Weize;LEI Xia(Affiliated Hospital of Jiujiang University,Jiujiang 332000,China)
出处 《中国医学创新》 CAS 2019年第36期117-120,共4页 Medical Innovation of China
关键词 凝血功能 血小板参数 慢性乙型肝炎 肝硬化 Coagulation function Platelet parameters Chronic hepatitis B Cirrhosis
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