摘要
目的:探讨高频重复经颅磁刺激(r TMS)治疗对酒依赖患者认知功能的影响。方法:75例酒依赖患者随机分为研究组(38例)和对照组(37例),均给予两组常规戒酒治疗;在此基础上给予研究组r TMS(10Hz)辅助治疗4周,对照组给予伪刺激。分别在治疗前后应用简易精神状态检查(MMSE)进行认知功能评分,应用诱发电位仪进行事件相关电位(ERP)检测。结果:①治疗后两组MMSE总分及各因子分均较治疗前明显提高,且研究组MMSE总分、时间定向、地点定向、注意和计算及短程记忆评分明显高于对照组(P<0.05或P<0.01);②治疗后两组ERP的N2、P3潜伏期较治疗前缩短,P3波幅较治疗前升高(P<0.05或P<0.01),与对照组相比,研究组改善更显著(P均<0.05);③治疗后患者MMSE总分与N2潜伏期呈负相关(r=-0.385,P=0.003),与P3波幅呈正相关(r=0.224,P=0.028)。结论:高频r TMS辅助治疗对酒依赖患者认知功能的改善有显著增效作用。
Objective:To investigate the effects of high frequency repeated transcranial stimulation(r TMS)on cognitive function in patients with alcohol dependence.Method:Seventy-five patients with alcohol dependence were randomly divided into study groups(38 cases)and control groups(37 cases),and both groups were treated with routine treatment.While the study group was treated with r TMS(10 Hz)adjuvant therapy and the control group was treated with pseudo-stimulation for 4 weeks.Before and after treatment,the cognitive function of the two groups was assessed by mini-mental state examination(MMSE)and the event-related potentials(ERP).Results:After treatment,the total scores and scores of each factor of MMSE in the two groups were significantly higher than those before treatment.The total scores of MMSE,score of time orientation,location orientation,attention and calculation,and short-term memory in the study group were significantly higher than those in the control group(P<0.05 or P<0.01);in the two groups,the latency of N2 and P3 of ERP were significantly shorter and the amplitude of P3 was significantly higher than that before treatment(P<0.05 or P<0.01);and those changes in the study group were more significant than those in the control group(all P<0.05).The correlation analysis showed that the total score of MMSE was negatively correlated with N2 latency(r=-0.385,P=0.003)and positively correlated with P3 amplitude(r=0.224,P=0.028).Conclusion:High-frequency r TMS adjuvant therapy has a significant synergistic effect on the cognitive function in patients with alcohol dependence.
作者
梁学军
刘立志
甘景梨
段惠峰
范亮亮
董毅
LIANG Xue-jun;LIU Li-zhi;GAN Jing-li;DUAN Hui-feng;FAN Liang-liang;DONG Yi(Department of Psychiatry,Mental Diseases Prevention and Treatment Institute of People's Liberation Army of China,91st Cen-tral Hospital,Jiaozuo 454003,China)
出处
《临床精神医学杂志》
2020年第1期40-43,共4页
Journal of Clinical Psychiatry
基金
全军医学科研计划(CWS12J071)
国家临床重点专科军队建设项目(11)
关键词
酒依赖
重复经颅磁刺激
认知功能
简易精神状态量表
事件相关电位
alcohol dependence
repetitive transcranial magnetic stimulation
cognitive function
mini-mental state examination
event-related potentials
