摘要
[目的]探讨老年乳腺癌病人化疗相关认知障碍现状及影响因素。[方法]选取188例住院进行化疗的老年乳腺癌病人为化疗组,同时选取192例年龄匹配的未化疗乳腺癌病人为对照组,采用一般资料问卷、癌症治疗功能评估-认知功能量表(FACT-Cog)、匹兹堡睡眠指数量表(PSQI)、癌症疲乏量表(CFS)对两组病人进行调查,分析化疗组老年乳腺癌病人化疗相关认知障碍的影响因素。[结果]化疗组病人FACT-Cog总分及感知到的认知障碍、认知能力、其他人的评价3个维度得分低于对照组(P<0.05)。不同年龄、文化程度及化疗周期的化疗组病人FACT-Cog得分比较差异有统计学意义(P<0.05)。化疗组病人PSQI得分为(8.68±4.51)分,CFS得分为(25.77±10.52)分,化疗组病人PSQI、CFS得分与FACT-Cog得分均呈负相关(P<0.01)。多重线性回归分析显示,化疗组病人年龄、化疗周期及PSQI、CFS得分是化疗相关认知障碍的影响因素(P<0.01),可解释总体变异度的57.8%。[结论]老年化疗乳腺癌病人认知功能低于未化疗的病人,年龄、化疗周期、睡眠质量及疲乏是老年乳腺癌病人化疗相关认知障碍的影响因素。
Objective:To investigate the status quo and influencing factors of chemotherapy-related cognitive impairment(CRCI)in elderly breast cancer patients.Methods:Totally 188 elderly patients with breast cancer who were in hospital for chemotherapy,were selected as the chemotherapy group.And 196 age-matched breast cancer patients without chemotherapy,were selected as the control group.The General Data Questionnaire,Functional Assessment of Cancer Therapy-Cognitive Function(FACT-Cog),Pittsburgh Sleep Index Scale(PSQI)and Cancer Fatigue Scale(CFS)were used to analyze the influencing factors of CRCI in elderly patients with breast cancer.Results:The total score of FACT-Cog and three dimensions scores of CogPCI,CogPCA and CogOth of patients in the chemotherapy group were lower than those in the control group(P<0.05).There were statical differences in scores of FACT-Cog of patients in chemotherapy group with different ages,culture levels and chemotherapy cycles(P<0.05).The scores of PSQI and CFS in chemotherapy group were 8.68±4.51 and 25.77±10.52 respectively.The PSQI and CFS scores were negatively correlated with FACT-Cog scores(P<0.01).Multiple linear regression analysis showed that the age,chemotherapy cycle,PSQI and CFS scores were the influencing factors of CRCI in chemotherapy group(P<0.01),which could account for 57.8%of the overall variability.Conclusions:The cognitive function of the elderly breast cancer patients in the chemotherapy group was lower than non-chemotherapy patients.And age,chemotherapy cycle,sleep quality and fatigue were the influencing factors of CRCI in the elderly breast cancer patients.
作者
张贤贤
贾智慧
张利霞
程远尊
ZHANG Xianxian;JIA Zhihui;ZHANG Lixia;CHENG Yuanzun(The Second Affiliated Hospital of Zhengzhou University,Henan 450014 China)
出处
《护理研究》
北大核心
2020年第3期425-429,共5页
Chinese Nursing Research
关键词
乳腺癌
老年人
化疗相关认知障碍
睡眠质量
疲乏
breast cancer
elderly
chemotherapy-related cognitive impairment
quality of sleep
fatigue
