摘要
子宫内膜异位症(endometriosis,EM)是一种常见的妇科良性疾病,病因机制复杂,缺乏统一认识,近年来,干/祖细胞学说逐渐受到学者认可。子宫内膜中存在干/祖细胞,研究人员对干/祖细胞特异性标志物的认识得到了进一步发展,这对分选干/祖细胞并进一步阐述其在EM发病机制中的作用有着重要意义。目前,研究较多的子宫内膜干细胞信号通路包括Wnt、Hedgehog、Notch、磷脂酰肌醇-3-激酶/蛋白激酶B、Smad/结缔组织生长因子、CXCL12/CXCR4等,这些信号通路可调节子宫内膜干/祖细胞的增殖和迁移从而参与EM的发生发展。探究信号通路如何调节干细胞参与EM的发病,有助于阐明EM的具体发病机制并为其治疗提供新方向。该文将对其展开综述。
Endometriosis(EM)is a common benign gynecological disease with complex pathogenesis and lack of unified understanding.In recent years,the theory of stem/progenitor cells has gradually been recognized by scholars.The presence of stem/progenitor cells in the endometrium and researchers’understanding of stem/progenitor cell specific markers has been further developed,which is of great significance for sorting stem/progenitor cells and further elucidating their roles in the pathogenesis of EM.At present,more endometrial stem cell signaling pathways have been studied including Wnt,Hedgehog,Notch,phosphatidylinositol-3-kinase/protein kinase B,Smad/connective tissue growth factor,CXCL12/CXCR4,etc.These signaling pathways can regulate stem cell involvement in the pathogenesis of EM.Exploring how signaling pathways to regulate stem cell involvement in the pathogenesis of EM can help elucidate the specific pathogenesis of EM and provide new directions for its treatment.This paper will summarize them.
作者
朱大秀
张真真
朱利
黄美华
万贵平
ZHU Daxiu;ZHANG Zhenzhen;ZHU Li;HUANG Meihua;WAN Guiping(Department of Gynecology,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210008,P.R.China;Department of Gynecology,Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing,Jiangsu 210008,P.R.China)
出处
《华西医学》
CAS
2020年第1期84-88,共5页
West China Medical Journal
基金
国家自然科学基金(81574016,81603655)
江苏省卫生和计划生育委员会科研课题(H2017033)
