摘要
目的探讨依巴斯汀联合糠酸莫米松治疗外阴湿疹(eczemaofvulva)的临床疗效和安全性。方法选取2016年8月至2017年9月就诊于首都医科大学附属北京同仁医院皮肤科的106例外阴湿疹患者作为研究对象,采用随机数表法将其分为治疗组和和对照组,每组53例患者。两组患者入院后接受常规对症处理,治疗组患者在此基础上采用糠酸莫米松联合依巴斯汀治疗,对照组患者在此基础上加用糠酸莫米松外搽治疗,观察两组患者治疗效果。结果治疗前,两组患者瘙痒程度、皮损面积、皮损颜色和肥厚程度评分结果比较,其差异均无统计学意义(均P>0.05);治疗后,两组患者各项指标均比治疗前有明显改善,治疗组患者改善效果显著优于对照组患者,其差异均具有统计学意义(均P<0.05);治疗组患者总有效率(96.2%)明显高于对照组患者(86.8%),其差异具有统计学意义(P<0.05);治疗期间,两组患者烧灼感、瘙痒刺痛感、嗜睡、眩晕等不良反应发生率比较,其差异均无统计学意义(均P>0.05)。结论依巴斯汀联合糠酸莫米松治疗外阴湿疹效果显著,能够迅速缓解患者临床症状,不良反应少,治疗安全性高,具有推广应用价值。
Objective To investigate the clinical efficacy and safety of ebastine combined with mometasone furoate in the treatment of vulvar eczema. Methods 106 patients with vulvar eczema from August 2016 to September 2017 were divided into treatment group(53 cases) and control group(53 cases) by random number table method. All patients received routine symptomatic treatment after admission. The control group was treated with external application of mometasone furoate and the treatment group were treated with the combination of furamate and obrasin. The therapeutic effects of the two groups were observed. Results Before treatment, there were no significant differences in the scores of pruritus, lesion area, skin color and hypertrophy between the two groups(all P>0.05). The scores of each index after treatment were significantly lower than those before treatment, more significant in the treatment group, with statistically significant differences(all P<0.05). The total effective rate in the treatment group(96.2%) was significantly higher than that in the control group(86.8%), with statistically significant difference(all P<0.05). During the treatment period, the incidence of adverse reactions such as burning sensation, itching tingling, lethargy, and dizziness between the two groups was not significantly different(P>0.05). Conclusions Ebastine combined with mometasone furoate is effective in the treatment of vulvar eczema, which can quickly relieve the clinical symptoms of patients, with few adverse reactions and high therapeutic safety and worthy of clinical application.
作者
张丽超
杨秀敏
ZHANG Lichao;YANG Xiumin(Department of Dermatology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)
出处
《中国性科学》
2019年第12期136-139,共4页
Chinese Journal of Human Sexuality
