摘要
目的探讨重症肺炎患者血浆N末端脑钠肽前体(NT-proBNP)、D-二聚体水平与炎症因子及预后的关系。方法选取2016年1月至2018年12月在该院接受治疗的重症肺炎患者104例作为重症肺炎组,根据患者入院28 d预后情况,将重症肺炎患者分为存活组(73例)和死亡组(31例)。另选取同期该院收治的100例普通社区获得性肺炎患者作为普通肺炎组,同期在该院体检的健康志愿者100例作为对照组。检测所有研究对象的NT-proBNP、D-二聚体、降钙素原(PCT)、白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)水平。结果重症肺炎组的NT-proBNP、D-二聚体、PCT、IL-6、hs-CRP水平和急性生理与慢性健康评分(APACHE)Ⅱ评分均明显高于普通肺炎组和对照组,差异有统计学意义(P<0.05)。死亡组的NT-proBNP、D-二聚体、PCT、IL-6、hs-CRP水平和APACHEⅡ评分均明显高于存活组,差异有统计学意义(P<0.05)。重症肺炎患者NT-proBNP、D-二聚体水平与PCT、IL-6、hs-CRP、APACHEⅡ评分均呈正相关(P<0.05)。NT-proBNP、D-二聚体均是重症肺炎患者死亡的危险因素。结论血浆NT-proBNP、D-二聚体在重症肺炎患者中呈高表达,与炎症因子呈正相关,均为重症肺炎患者死亡的危险因素。
Objective To investigate the relationship between the levels of N-terminal pro brain natriuretic peptide(NT-proBNP),D-dimer and inflammatory factors and prognosis in patients with severe pneumonia.Methods A total of 104 patients with severe pneumonia who were treated in the hospital from January 2016 to December 2018 were selected as the severe pneumonia group.According to the 28 d prognosis,the patients with severe pneumonia were divided into survival group(73 cases)and death group(31 cases).In addition,100 patients with community-acquired pneumonia in the same period were selected as the general pneumonia group,and 100 healthy volunteers in the same period were selected as the control group.The levels of NT-proBNP,D-dimer,PCT,IL-6 and hs-CRP were measured.Results The levels of NT-proBNP,D-dimer,PCT,IL-6,hs-CRP,and APACHEⅡscores in severe pneumonia group were significantly higher than those in common pneumonia group and control group(P<0.05).The levels of NT-proBNP,D-dimer,PCT,IL-6,hs-CRP and APACHEⅡscores in the death group were significantly higher than those in the survival group(P<0.05).The levels of NT-proBNP and D-dimer were positively correlated with PCT,IL-6,hs-CRP and APACHEⅡscores(P<0.05).NT-proBNP and D-dimer were risk factors of death in patients with severe pneumonia.Conclusion NT-proBNP and D-dimer are highly expressed in patients with severe pneumonia,and are positively correlated with inflammatory factors,which are risk factors of death in patients with severe pneumonia.
作者
汤炜
许超
TANG Wei;XU Chao(Department of Clinical Laboratory,Lu′an Hospital Affiliated to Anhui Medical University,Lu′an,Anhui 237006,China;Department of Laboratory Pathology,the 72nd Army Hospital of PLA,Xuchao,Huzhou,Zhejiang 313000,China)
出处
《国际检验医学杂志》
CAS
2020年第3期297-300,304,共5页
International Journal of Laboratory Medicine
基金
安徽省卫生和计划生育委员会科研计划项目(2016QH006)
关键词
重症肺炎
N末端脑钠肽前体
D-二聚体
炎症因子
预后
severe pneumonia
N-terminal pro brain natriuretic peptide
D-dimer
inflammatory factors
prognosis
