摘要
目的探讨内源性缓激肽释放酶表达水平对缺血性脑卒中预后的影响。方法回顾性选取2017年1月至2018年8月复旦大学附属华山医院收治的缺血性脑卒中患者76例作为观察组,根据病情复发情况分为复发组(n=38)与非复发组(n=38),并选择同期来复旦大学附属华山医院体检的健康者76例作为对照组。比较各组内源性缓激肽释放酶的表达水平。结果观察组患者的血清激肽释放酶-1(KLK-1)[(1.42±0.14)μg/L]、血清激肽释放酶-6(KLK-6)[(3.19±0.11)μg/L]水平显著高于对照组的KLK-1[(1.10±0.17)μg/L]、KLK-6[(3.01±0.12)μg/L]差异具有统计学意义(P<0.05)。复发组患者的血清KLK-1[(1.68±0.09)μg/L]、[KLK-6(3.43±0.10)μg/L]水平显著高于非复发组的KLK-1[(1.25±0.11)μg/L]、[KLK-6(3.11±0.07)μg/L]差异具有统计学意义(P<0.05)。结论内源性缓激肽释放酶是影响缺血性脑卒中患者预后的危险因素,其表达水平越高则患者的预后效果越差,可将内源性缓激肽释放酶作为缺血性脑卒中预后评估的辅助指标。
Objective To investigate the effect of endogenous bradykinin releasing enzyme expression on the prognosis of ischemic stroke.Methods 76 patients with ischemic stroke admitted to Huashan Hospital Affiliated to Fudan University from January 2017 to August 2018 were retrospectively analyzed as observation group.They were divided into recurrence group(n=38) and non-recurrence group(n=38) according to the recurrence of the disease.76 healthy persons who came to Huashan Hospital Affiliated to Fudan University for physical examination in the same period were selected as control group.The expression levels of endogenous bradykinin-releasing enzymes in each group were compared.Results The levels of serum kallikrein-1(KLK-1) [(1.42±0.14)μg/L],kallikrein-6(KLK-6) [(3.19±0.11)μg/L] in the observation group were significantly higher than those in the control group [(1.10±0.17)μg/L],KLK-6 [(3.01±0.12)μg/L],with significant difference(P <0.05).The serum levels of KLK-1 [(1.68±0.09)μg/L],[KLK-6(3.43±0.10)μg/L] in therelapsed group weresignificantly higher than those in the non-relapsed group [(1.25±0.11)μg/L],[KLK-6(3.11±0.07)μg/L],and the difference was statistically significant(P <0.05).Conclusion Endogenous bradykinin releasing enzyme is a risk factor affecting the prognosis of patients with ischemic stroke.The higher its expression level,the worse the prognosis of patients.Endogenous bradykinin-releasing enzyme can be used as an auxiliary index for prognosis evaluation of ischemic stroke.
作者
王政
苏璐
陆素洁
WANG Zheng;SU Lu;LU Su-jie(Department of Neurology,Fudan University Affiliated to Huashan Hospital,Shanghai 200030,China;Department of Neurology,Civil Aviation Shanghai Hospital,Shanghai 200336,China)
出处
《临床和实验医学杂志》
2020年第3期254-256,共3页
Journal of Clinical and Experimental Medicine
基金
国家青年科学基金支持项目(编号:81501134)
关键词
缺血性脑卒中
内源性缓激肽释放酶
预后
Ischemic stroke
Endogenous bradykinin releasing enzyme
Prognosis
