摘要
目的采用阿托伐他汀钙联合依折麦布药物,对患有冠心病的患者进行医治,观察其临床疗效。方法将2017年2月-2019年1月该院收治的110例冠心病患者,依据盲选的原则进行分组,分成对照组与实验组。对照组:给患者使用阿托伐他汀钙;实验组:给予患者阿托伐他汀钙联合依折麦布药物进行治疗。对两组患者疗效、血脂水平及不良反应进行比较。结果①实验组总有效率(92.7%)高于对照组(65.5%),数据差异有统计学意义(χ^2=12.37,P<0.05);②治疗前,两组患者的血清总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDC-C)和三酰甘油(TG)差异无统计学意义(P>0.05);治疗后,实验组TC、HDLC、LDC-C、TG水平均低于对照组,差异有统计学意义(P<0.001);③实验组患者的头痛、肌痛、血管神经性水肿、肠胃反应等不良反应程度明显低于对照组,数据差异有统计学意义(P<0.05)。结论采用阿托伐他汀钙联合依折麦布药物治疗后,疗效明显,可用于临床用药。
Objective To observe the clinical efficacy of atorvastatin calcium combined with ezetimibe in patients with coronary heart disease. Methods A total of 110 patients with coronary heart disease admitted to the hospital from February 2017 to January 2019 were divided into control group and experimental group according to the principle of blind selection. Control group: atorvastatin calcium was given to patients;experimental group: patients were given atorvastatin calcium combined with ezetimibe medication. The efficacy, blood lipid levels and adverse reactions of the two groups were compared. Results 1.The total effective rate of the experimental group(92.7%) was higher than that of the control group(65.5%), the data were statistically significant (χ^2=12.37, P<0.05);2.before the treatment, the serum total cholesterol(TC) of the two groups of patients, high-density lipoprotein(HDL-C), low-density lipoprotein(LDC-C) and triglyceride(TG) were not significantly different(P>0.05);after treatment, experimental group TC, HDL-C, LDC-C, TG level was lower than that of the control group, and the difference was statistically significant(P<0.001). 3.The degree of adverse reactions such as headache, myalgia, angioedema, and gastrointestinal reaction in the experimental group was significantly lower than that in the control group, The data is statistically significant(P<0.05). Conclusion After treatment with atorvastatin calcium combined with ezetimibe, the curative effect is obvious and can be used for clinical medication.
作者
王景
WANG Jing(Department of Cardiology,Suzhou Jinchang Hospital,Suzhou,Jiangsu Province,215000 China)
出处
《世界复合医学》
2019年第12期186-188,共3页
World Journal of Complex Medicine
关键词
阿托伐他汀钙
依折麦布药物
冠心病
Atorvastatin calcium
Ezetimibe drug
Coronary heart disease
