摘要
利用自制的超临界流体抗溶剂装置,以多肽化合物为模型药物,研究压力、温度、进样速率和样品浓度等工艺参数对微粉粒径的影响,并采用扫描电镜、热重分析仪、X射线衍射仪等对制备的微粉进行表征。结果表明:压力、温度和样品浓度3个工艺参数对微粉的粒径没有显著性影响,微粉微观形貌主要为球形;微粉热稳定性未发生明显变化;微粉主要为无定形结构;制备得到空气动力学粒径约为1.0 pum的微粉,符合吸入式给药对微粉粒径的要求。
In this paper,the polypeptide powder was prepared by an experimental apparatus for supercritical anti solvent process,and the effects of process parameters including pressure,temperature,flow rate and concentration on the particle size were investigated experimentally.The characteristics of the powder were carried out by SEM,TGA and XRD.The results show that there is no signifigant effect of pressure,temperature and concentration on particle size and the morphology of micro-particles prepared is mainly spherical.There is no significant change in the thermal stability of micro-powder.The powder is mainly amorphous structure.The aerodynamic particle size of the powder is about 1.0 jxm,which is suitable for inhalation delivery system.
作者
黄永鹏
陈博
唐慧
钟辉
孟祥燕
焦剑岚
HUANG Yongpeng;CHEN Bo;TANG Hui;ZHONG Hui;MENG Xiangyan;JIAO Jianlan(Research Institute of Chemical Defense,Beijing 102205,China)
出处
《中国粉体技术》
CAS
CSCD
2020年第2期41-47,共7页
China Powder Science and Technology
基金
国防预先研究项目，编号:LD4B04
关键词
吸入式给药
超临界流体抗溶剂
多肽化合物
微粉
inhalation drug delivery
supercritical antisolvent process
polypeptide
microparticles
