摘要
载脂蛋白是一类能与血浆脂质结合、运输血脂到机体各组织进行代谢及利用的蛋白质。国内外研究发现载脂蛋白基因发生突变,形成不同等位基因型及不同表型的载脂蛋白,从而导致脂质代谢紊乱及心脑血管疾病的发生。众所周知,高脂血症是冠心病的独立危险因素之一,现就目前报道及研究的载脂蛋白基因多态性与冠心病的研究进展进行综述。
Apolipoprotein is a type of protein that binds to plasma lipids and transports blood lipids to various tissues of the body for metabolism and utilization.Studies at home and abroad have found mutations in the apolipoprotein gene to form apolipoproteins with different alleles and different phenotypes,leading to disorders of lipid metabolism and cardiovascular and cerebrovascular diseases.It is well known that hyperlipidemia is one of the independent risk factors for coronary heart disease.This article reviews the current research and research on apolipoprotein gene polymorphism and coronary heart disease research progress.
作者
张燕
曾甜
徐健
刘丽
ZHANG Yan;ZENG Tian;XU Jian;LIU Li(North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Cardiology,The Second People s Hospital of Yibin City,Yibin 644000,Sichuan,China)
出处
《心血管病学进展》
CAS
2019年第9期1294-1297,共4页
Advances in Cardiovascular Diseases
关键词
载脂蛋白
基因多态性
冠心病
Apolipoprotein
Gene polymorphism
Coronary heart disease
