摘要
牙周病的始动因子为菌斑生物膜,近年来菌斑学说越来越倾向于牙周微生态失调。目前牙周病经典的治疗方法为机械性去除菌斑,但疗效存在个体差异性,部分患者需要辅助其他治疗方法。益生菌具有重建宿主微生物群落、调节免疫炎症反应的特点,可能起到改善牙周病微生态的作用。本文从牙周相关疾病分类角度,对目前益生菌生态调节在牙周炎、牙龈炎、口腔异味及种植体周围疾病防治上的临床效应、作用机制及临床应用加以总结。
The initiating factor of periodontal diseases is plaque biofi lm.In recent years,plaque hypothesis becomes increasingly inclined to the disruption of microbial homeostasis.Classic treatment method is mechanical plaque removal.However,individual differences exist in the curative effect,and some patients need to be assisted with other treatment methods.The role of probiotics in reconstructing host microbial community and regulating immune infl ammatory responses may result in certain improvement in the microecology of periodontal diseases.This review summarises the clinical effects,mechanism and clinical application of probiotics for prevention and treatment of periodontitis,gingivitis,oral malodour and periimplant diseases from the perspective of the classifi cation of periodontal diseases.
作者
刘琳
周婕妤
吴亚菲
赵蕾
Liu Lin;Zhou Jieyu;Wu Yafei;Zhao Lei(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Periodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处
《国际口腔医学杂志》
CAS
CSCD
2020年第2期131-137,共7页
International Journal of Stomatology
基金
国家自然科学基金(81371150,81771077)
四川省重点研发项目(2018SZ0161)~~
关键词
牙周病
益生菌
临床效应
机制
临床应用
periodontal diseases
probiotics
clinical effect
mechanism
clinical application
