摘要
目的探讨血清1,25-二羟维生素D3水平与肺癌临床病理特征及预后的关系。方法将103例肺癌患者纳入肺癌组,另将同期体检的62例健康体检者作为对照组,采集2组晨起空腹外周静脉血,应用酶联免疫吸附法(ELISA)检测血清1,25-二羟维生素D3水平,比较2组血清1,25-二羟维生素D3水平,并分析肺癌患者血清1,25-二羟维生素D3水平与临床病理特征及预后的关系。结果ELISA检测结果显示,肺癌组的血清1,25-二羟维生素D3水平[(29.24±5.37)μg/l]明显低于对照组[(40.16±6.26)μg/l],2组相比差异具有统计学意义(P<0.05)。不同性别、年龄、肿瘤直径、病理分型的肺癌患者血清1,25-二羟维生素D3水平相比,差异无统计学意义(P>0.05);但不同TNM分期、组织分化程度、有无淋巴结转移及远端转移的肺癌患者血清1,25-二羟维生素D3水平相比,差异有统计学意义(P>0.05)。1,25-二羟维生素D3缺乏组(≤20μg/l)2年生存率为30.00%(18/60),正常组(>20μg/l)患者的2年生存率为63.83%(30/47),缺乏组患者2年生存率明显低于正常组患者(P<0.05)。结论血清1,25-二羟维生素D3水平降低可能与肺癌的发生及恶性程度有关,提高1,25-二羟维生素D3水平可能有助于改善肺癌患者的预后。
Objective To investigate the relationship between serum 1,25-dihydroxyvitamin D3 level and clinicopathological features and prognosis of lung cancer.Methods 103 patients with lung cancer were enrolled in the lung cancer group,and 62 healthy people in the same period were taken as the control group.Fasting peripheral venous blood was collected from the 2 groups in the morning,and serum levels of 1,25-dihydroxyvitamin D3 were detected by enzyme-linked immunosorbent assay(ELISA).The serum levels of 1,25-dihydroxyvitamin D3 were compared between the 2 groups,and the relationship between serum levels of 1,25-dihydroxyvitamin D3 and clinicopathological characteristics and prognosis in patients with lung cancer was analyzed.Results The results of ELISA showed that the serum level of 1,25-dihydroxyvitamin D3[(29.245.37)μg/l]in lung cancer group was significantly lower than that of the control group[(40.166.26)μg/l],and there was a significant difference between the 2 groups(P<0.05).There was no significant difference in serum 1,25-dihydroxyvitamin D3 levels among patients with lung cancer of different gender,age,tumor diameter and pathological type(P>0.05),but there was statistical difference in serum 1,25-dihydroxyvitamin D3 levels among patients with lung cancer of different TNM stages,degree of tissue differentiation,lymph node metastasis and distal metastasis(P>0.05).The 2-year survival rate was 30.00%(18/60)in the 1,25-dihydroxyvitamin D3 deficiency group(<20μg/l)and 63.83%(30/47)in the normal group(>20μg/l).The 2-year survival rate in the deficiency group was significantly lower than that of the normal group(P<0.05).Conclusion The decrease of serum 1,25-dihydroxyvitamin D3 level may be related to the occurrence and malignancy of lung cancer.Increasing serum 1,25-dihydroxyvitamin D3 level may be helpful to improve the prognosis of lung cancer patients.
作者
安晨萍
王志华
巩翠珂
张萍
安艳荣
睢歆
AN Chenping;WANG Zhihua;GONG Cuike(Xingtai People's Hospital,Xingtai,054000)
出处
《实用癌症杂志》
2020年第2期196-199,共4页
The Practical Journal of Cancer
关键词
肺癌
1
25-二羟维生素D3
临床病理特征
预后
Lung cancer
1
25-dihydroxyvitamin D3
Clinicopathological features
Prognosis
