摘要
目的探讨上皮细胞黏附分子(EP-CAM)、神经细胞黏附分子1(N-CAM1)及C-KIT与原发性肝癌分级、转移及患者预后的关系。方法收集80例原发性肝癌患者作为观察组,选择同期行手术治疗的50例肝硬化及乙型肝炎患者作为对照组,均收集患者病理组织标本,采用免疫组化法测定肝癌组织EP-CAM、N-CAM1、C-KIT表达情况,分析EP-CAM、N-CAM1、C-KIT与原发性肝癌临床病理特点及患者预后的关系。结果观察组EP-CAM、N-CAM1、C-KIT阳性表达率均高于对照组(P<0.05);高AFP水平、无包膜或包膜不完整、低中分化肿瘤、临床分期为Ⅲ~Ⅳ期、病理类型为胆管上皮癌、混合型肝癌及出现肝内外转移的肝癌患者EP-CAM、N-CAM1、C-KIT阳性率较高(P<0.05);肝癌患者1年、2年、3年生存率分别为72.50%、53.75%、37.50%,随访3年存活患者,EP-CAM、N-CAM1、C-KIT阳性率低于1年及2年存活患者(P<0.05)。结论EP-CAM、N-CAM1、C-KIT表达水平与原发性肝癌患者AFP水平、肿瘤包膜情况、分化程度、临床分期、组织学类型及预后均有一定的关系,且参与肝癌侵袭、转移过程。
Objective To investigate the relationship between epithelial cell adhesion molecule(EP-CAM),nerve cell adhesion molecule 1(N-CAM1),C-KIT and the grade,metastasis and prognosis of primary liver cancer.Methods 80 patients with primary liver cancer were selected as the observation group.Another 50 patients with hepatic cirrhosis and hepatitis B who underwent surgical treatment during the same period were selected as the control group.The pathological tissues were collected from patients to determine the expression of EP-CAM,N-CAM1 and C-KIT in liver cancer tissues by the immunohistochemical method.The relationship between EP-CAM,N-CAM1,C-KIT and clinical pathological characteristics,prognosis of primary liver cancer was analyzed.Results The positive expression rates of EP-CAM,N-CAM1 and C-KIT in the observation group were higher than those in the control group(P<0.05).The positive rates of EP-CAM,N-CAM1 and C-KIT were relatively higher in patients with high AFP level,patients without capsule or with incomplete capsule,patients with lowly or moderately differentiated tumors,patients with tumors in clinical stage III-IV,patients with pathological type of cholangiocarcinoma,patients with mixed liver cancer and patients with intrahepatic and extrahepatic metastasis(P<0.05).The 1-year,2-year and 3-year survival rates of patients with liver cancer were 72.50%,53.75%and 37.50%,respectively.The positive rates of EP-CAM,N-CAM1 and C-KIT in follow-up 3-year survivors were lower than those in 1-year and 2-year survivors(P<0.05).Conclusion The expression levels of EP-CAM,N-CAM1 and C-KIT are correlated with the AFP level,tumor capsule,differentiation degree,clinical stage,histological type and the prognosis of patients with primary liver cancer,and they are involved in the process of invasion and metastasis of liver cancer.
作者
郑国文
王丽
ZHENG Guowen;WANG Li(Leshan Second People's Hospital,Leshan,614000)
出处
《实用癌症杂志》
2020年第2期200-204,共5页
The Practical Journal of Cancer
