摘要
为探讨藏药复方三味豆蔻汤散水提物对小鼠的镇静催眠作用,观察了三味豆蔻汤散水提物对小鼠自发活动次数的影响、阈下剂量戊巴比妥钠致小鼠入睡率影响以及阈上剂量戊巴比妥钠致小鼠睡眠时间影响.结果显示小鼠自主活动实验中,与空白对照组相比,中、高剂量三味豆蔻汤散对小鼠的自主活动次数均有明显抑制作用(P<0.05),其镇静效果明显;协同戊巴比妥钠催眠实验结果显示,与空白对照组相比,低、中、高三种剂量三味豆蔻汤散均显著增加阈下剂量戊巴比妥钠小鼠的入睡率(P<0.05),能缩短阈上剂量戊巴比妥钠小鼠的入睡潜伏期(P<0.05),延长睡眠持续时间(P<0.05),且中剂量效果最好.表明藏药三味豆蔻汤散水提物对小鼠具有明显的镇静、催眠作用.
To study the hypnotic and sedative effects of water extract of Sugmel Sumtang on mice,it observed the independent active number of times,the sleeping rate of pentobarbital sodium of subthreshold dosage,and the sleeping time of mice induced by Sugmel Sumtang.The results showed that high,middle-dose of Sugmel Sumtang showed significant inhibitory effects on the independent active number of times compared with blank sample(P<0.05).The results of hypnotic test with pentobarbital demonstrated that the sleeping rate of subthreshold dose of sodium pentobarbital was obviously increased,the incubation period of fallen asleep was shortened,and the sleep duration was extended by high,middle,low-dose groups of Sugmel Sumtang compared with blank sample,respectively(P<0.05),And the best one is the middle dose treatment.Collectively,the water extract of Sugmel Sumtang has good sedative and hypnotic effects.
作者
李毛加
张金魁
李海丽
南措吉
扎西吉
才让南加
LI Mao-jia;ZHANG Jin-kui;LI Hai-li;NAN Cuo-ji;ZA Xi-ji;CAI RANG Nan-jia(College of Pharmacy,Qinghai Nationalities University,Xining 810007,China;Key Laboratory of Plant Resources of Qinghai-Tibet Plateau in Chemical Research,Xining 810007,China)
出处
《辽宁大学学报（自然科学版）》
CAS
2020年第1期65-70,共6页
Journal of Liaoning University：Natural Sciences Edition
基金
青海省自然科学基金(2019-ZJ-7088)
关键词
三味豆蔻汤散
镇静
催眠
药效学
Sugmel Sumtang
hypnotic
sedative
pharmacodynamics
