摘要
目的分析合并2型糖尿病(T2DM)的幽门螺杆菌(Hp)感染胃病患者进行标准四联疗法根除Hp治疗前后血清胃蛋白酶原(PG)和胃泌素17(G-17)的变化及临床意义。方法合并T2DM的三种胃病为功能性消化不良85例(A组)、消化性溃疡60例(B组)和慢性萎缩性胃炎24例(C组)。非合并T2DM的三种胃病为功能性消化不良112例(D组)、消化性溃疡87例(E组)和慢性萎缩性胃炎31例(F组)。合并T2DM的A、B和C组中Hp阳性进一步分为功能性消化不良(A1组)、消化性溃疡(B1组)和慢性萎缩性胃炎(C1组)。检测A^E组Hp阳性率,比较A1~C1组Hp根除率及空腹血清PGⅠ、PGⅡ、PGⅠ/PGⅡ及G-17水平。结果A组Hp阳性率高于D组(61.2%vs.44.6%)(P<0.05)。B组Hp阳性率高于D组(70.0%vs.52.9%)(P<0.05)。C组Hp阳性率高于F组(87.5%vs.61.3%)(P<0.05)。A1、B1和C1组Hp根除率分别为94.23%、83.33%和80.95%,组间比较无统计学差异(P>0.05)。A1组和B1组Hp根除后PGⅠ、PGⅡ及G-17水平降低(P<0.01或P<0.05),C1组Hp根除后PGⅡ水平降低(P<0.01),而PGⅠ/PGⅡ升高(P<0.05)。结论合并T2DM的不同胃病患者Hp阳性率升高,Hp根除前后存在一定程度血清PG、G-17水平变化。
Objective To analyze the changes and clinical significance of serum pepsinogen(PG)and gastrin 17(G-17)before and after Helicobacter pylori(Hp)eradication in the patients with gastric diseases complicated with type 2 diabetes mellitus(T2 DM).Methods The three gastric diseases complicated with T2 DM were functional dyspepsia in 85 cases(group A),peptic ulcer in 60 cases(group B)and chronic atrophic gastritis in 24 cases(group C).The three gastric diseases without T2 DM were functional dyspepsia in 112 cases(group D),peptic ulcer in 87 cases(group E)and chronic atrophic gastritis in 31 cases(group F).The Hp positive rates of groups of A-F were calculated,Hp eradicate rate and fasting serum levels of PGⅠ,PGⅡ,PGⅠ/PGⅡand G-17 were compared among groups of A1-C1.Results The Hp positive rate in group A was higher than that in group D(61.2%vs.44.6%),which in group B was higher than that in group D(70.0%vs.52.9%),which in group C was higher than that in group F(87.5%vs.61.3%)(P<0.05).The eradication rates of Hp in A1,B1 and C1 groups were 94.23%,83.33%and 80.95%,respectively(P>0.05).Compared to before,the levels of PGⅠ,PGⅡand G-17 in groups of A1 and B1 were decreased after Hp eradication(P<0.01 and P<0.05).Compared to before,the level of PGⅡwas decreased(P<0.01)and the PGⅠ/PGⅡratio was increased after Hp eradication in group C1(P<0.05).Conclusion The positive rate of Hp in T2 DM patients withgastric diseases is increased.There is a certain degree of change in serum pepsinogen and G-17 levels before and after Hp eradication.
作者
王昊
曲红光
WANG Hao;QU Hongguang(Department of Gastroenterology,Fifth Affiliated Hospital,Guangzhou Medical University,Guangzhou 510700,CHINA)
出处
《江苏医药》
CAS
2019年第12期1257-1260,共4页
Jiangsu Medical Journal
基金
广州市卫生局医药卫生科技项目(20171A010324)
关键词
幽门螺杆菌
胃病
2型糖尿病
胃蛋白酶原
胃泌素17
Helicobacter pylori
Gastric disease
Type 2 diabetes mellitus
Pepsinogen
Gastrin 17
