摘要
目的:观察温通汤加减治疗动脉硬化性闭塞症(ASO)的疗效及对血流动力学状态、凝血功能的影响。方法:选取我院2017年1月~2018年5月收治的80例ASO患者为研究对象,采用随机数字表方法分为治疗组(40例)和对照组(40例),对照组予以常规治疗,治疗组在对照组的基础上予以温通汤加减治疗,1个月为1个疗程,两组均治疗3个疗程。比较两组的临床疗效、治疗前后的中医症候积分、血流动力学状态(血浆黏度、血沉速率、红细胞体积、纤维蛋白原)、凝血功能[凝血酶原时间(PT)、活化的部分凝血活酶时间(APTT)]、内皮素(ET)及一氧化氮(NO)水平,比较两组治疗期间不良反应的发生情况及指标变化、症状改善情况。结果:治疗组的治疗总有效率(95.00%)显著高于对照组(77.50%)(P<0.05);治疗组的各项中医症候积分显著低于对照组(P<0.05);治疗组的血浆黏度、血沉速率、纤维蛋白原显著低于对照组(P<0.05);治疗组的ET显著低于对照组(P<0.05),PT、APTT及NO显著高于对照组(P<0.05);两组均未见明显毒副反应。结论:温通汤治疗ASO通过抗凝作用显著改善血液流变异常,进而缓解临床表现,疗效肯定。
Objective:To explore the efficacy of using Modified Wentong Decoction in the treatment of arteriosclerotic occlusion(ASO)and its effect on hemodynamic status and coagulation function.Methods:Eighty patients with ASO admitted to our hospital from January 2017to May 2018were selected for the study and were randomly divided into treatment group(40cases)and controlled group(40cases)according to the random number table method.The controlled group was given routine treatment,and treatment group was given Modified Wentong Decoction on the basis of the controlled group,and the two groups were treated for 3courses with 1 month for 1 course.The clinical efficacy,TCM syndromes scores,hemodynamic status(plasma viscosity,erythrocyte sedimentation rate,erythrocyte volume,fibrinogen),coagulation function[prothrombin time(PT),activated partial thromboplastin time(APTT)],endothelin(ET)and nitric oxide(NO)before and after treatment were compared between the two groups.And the occurrence of adverse reactions during treatment was compared between the two groups.Results:The total effective rate of the treatment group was significantly higher than that in the controlled group(95.00%vs 77.50%)(P<0.05).The scores of TCM symptoms in the treatment group were significantly lower than those in the controlled group(P<0.05).The plasma viscosity,erythrocyte sedimentation rate and fibrinogen in the treatment group were significantly lower than those in the controlled group(P<0.05).The ET in the treatment group was significantly lower than that in the controlled group(P<0.05),and the PT,APTT and NO were significantly higher than those in the controlled group(P<0.05).There were no significant side effects in the two groups.Conclusion:Wentong Decoction for ASO can significantly improve hemorheology abnormalities through anticoagulation,and thus can relieve clinical manifestations,and it has affirmative efficacy.
作者
张海丽
王景
于洋
麻继超
ZHANG Haili;WANG Jing;YU Yang(Department of Vascular Diseases,the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin Helongjiang 150001,China)
出处
《四川中医》
2020年第2期85-88,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
黑龙江中医药大学校科研基金资助项目(编号:201812)
关键词
温通汤
动脉硬化性闭塞症
血流动力学
凝血功能
Wentong Decoction
Arteriosclerotic occlusion
Hemodynamics
Coagulation function
