摘要
目的:探讨叶天士在《临证指南医案》中治疗妇人癥瘕的用药规律及其特点。方法:整理《临证指南医案》中关于癥瘕的医案,采用Excel 2010、SPSS 19.0、SPSS Modeler 15.0软件对医案中的药物频数分析、药性药味、归经特点分析、关联规则分析、聚类分析和关联网络分析。结果:茯苓、当归、香附的频数最高;补虚药的频数最高;药物性味多以辛温为主;归肝脾经的药物最多。关联规则分析包含2种药物的药组有8组:川楝子、延胡索;当归、白芍;当归、肉桂;茯苓、地黄;小茴香、青葱管;当归、桃仁;川楝子、青皮;当归、地黄。包含3种药物的药组有3组:茯苓、小茴香、当归;地黄、茯苓、当归;当归、青葱管、小茴香。聚类分析最终形成4个聚类,分别具有温经通脉、散瘀止痛;活血清热、调经止痛;健脾利水、养血调经;疏肝行气、散寒止痛的功效。关联网络分析得出的核心药物为白术、川楝子、当归、人参、桃仁、地黄、香附、延胡索、甘草、茯苓、陈皮、青葱管。结论:叶天士治疗癥瘕时,根据病情特点,最常用茯苓、当归和香附,最注重温经散结之法,并配以养血活血、疏肝解郁、温中健脾等治法。
Objective:To investigate the rule and characteristics of YE Tian-shi’s medication in the treatment of women with symptoms in the Clinical Proceedings in Clinical Guidelines for Medical Records.Methods:We organized the medical case concerning the symptoms in the Clinical Proceedings in Clinical Guidelines for Medical Records.Excel 2010,SPSS 19.0 and SPSS Modeler 15.0 software were applied to carry out the drug frequency analysis,drug taste,returning characteristics analysis,association rule analysis,cluster analysis and association network analysis in the medical case.Results:The frequency of Poria cocos(Fulin),Angelica(Danggui)and Cyperus(Xiangfu)was the highest;the frequency of tonic medicine was the highest;the drug-like taste was mainly Xinwen;the drug with liver and spleen meridian was the most;the association rule analysis included 8 groups of drugs with 2 drugs,including"Fructus Melia(Chuanlianzi)and Corydalis tuber(Yanhusuo)""Angelica(Dangui)white peony(Baishao)""Angelica(Dnagui)and Cinnamon(Rougui)""Poria(Fuling)and Rehmannia(Dihuang)""cumin(Xiaohuixiang)and shallot tube(Qingcongguan)""Angelica(Dangui)and peach kernel(Taoren)";"Fructus Melia(Chuanlianzi)and Green skin(Qingpi)"and"Angelica(Dnagui)Rehmannia(Dihuang)".There are three groups of drugs containing three kinds of drugs,including"Poria(Fuling),Fennel(Xiaohuixiang)and Angelica(Dangui)""Rehmannia root(Dihuang),Poria(Fuling)and Angelica rehmannia(Dangui)"and"Angelica(Dangui),shallot tube(Qingconggruan)and fennel(Xiaohuixiang)".Cluster analysis finally formed 4 clusters,respectively,with"warming meridians,clearing blood stasis and relieving pain""promoting blood circulation,clearing heat,regulating menstruation and relieving pain""invigorating the spleen,benefiting the water,nourishing the blood and regulating the meridians"and"soothing liver,promoting Qi,dispersing cold and relieving pain".The core drugs obtained from the network analysis were Atractylodes Rhizome(Baizhu),Fructus Melia(Chuanlianzi),Angelica(Dangui),Ginseng(Renshen),Peach Kernel(Taoren),Rehmannia root(Dihuang),Cyperus(Xiangfu),Rhizoma Corydalis(Yanhusuo),Liquorice(Gancao),Poria(Fuling),Tangerine peel(Chenpi)and Shallot tube(Qingconggruan).Conclusion:When YE Tian-shi treats symptoms,according to the characteristics of the disease,Poria(Fuling),Angelica(Dangui),and Cyperus(Xiangfu)are the most commonly used drugs,and the most emphasis on the method of warming and stagnation,with nourishing blood and promoting blood circulation,relieving stagnation of liver Qi,Wenzhong Jianpi and other treatments。
作者
胡嘉怡
朱虹丽
王晓涛
赵小云
饶龙
HU Jia-yi;ZHU Hong-li;WANG Xiao-tao;ZHAO Xiao-yun;RAO Lng(Shaanxi University of Traditional Chinese Medicine,Xianyang Shaanxi 712000,China;Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang Shaanxi 712000,China)
出处
《中医药导报》
2019年第23期40-43,56,共5页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词
临证指南医案
叶天士
癥瘕
用药规律
数据挖掘
Clinical guidelines for medical records
YE Tian-shi
mass mass
law of medication
data mining
