摘要
目的 应用三维有限元方法分析钛(Ti)、钽(Ta)、聚醚醚酮(PEEK)、羟基磷灰石(HA)多孔支架在即刻负载下修复兔股骨缺损的力学特性,从生物力学角度探究最佳多孔支架材料。方法 通过CBCT扫描,结合Mimics、Solid Works、Geomagic Studio、ANSYS等软件设计建立不同愈合阶段多孔支架修复兔股骨缺损的即刻加载模型,计算支架及其周围组织的应力、应变。结果 多孔支架的最大等效应力随着骨愈合过程而减小。在肉芽组织及纤维组织模型中,多孔支架最大等效应力与屈服强度的比值:HA>Ta>PEEK>Ti,其中HA多孔支架的最大等效应力大于其屈服强度;多孔支架周围组织适宜应变单元数:PEEK>Ta>Ti>HA;多孔支架周围组织可能断裂应变单元数:HA>Ta>PEEK>Ti。结论 HA多孔支架并不满足即刻负载的要求,不能在即刻负载情况下引导良好骨愈合。PEEK多孔支架弹性模量与人体骨组织相近,能引导良好骨愈合,是即刻负载下较为理想的多孔支架材料。研究结果可为临床即刻负载下多孔支架材料的选择提供参考。
Objective To investigate the biomechanical behavior of porous scaffold with different materials(Ti,Ta,PEEK,HA)for repairing rabbit femur defects under immediate loading by three-dimensional finite element analysis(FEA),so as to explore the best porous scaffold material from the perspective of biomechanics.Methods The CBCT combined with software such as Mimics,SolidWorks,Geomagic Studio,ANSYS were used to establish an immediate loading model for the repair of rabbit femur defects with porous scaffolds at different stages of bone healing.The stress and strain distributions on the scaffolds and the surrounding tissues were calculated.Results The maximum equivalent stress of porous scaffold decreased along with the bone healing.In the granulation tissue and fibrous tissue model,the ratio of the maximum equivalent stress to the yield strength of porous scaffold was:HA>Ta>PEEK>Ti.The maximum equivalent stress of the HA porous scaffold was greater than its yield strength.The number of suitable strain elements in tissues around the porous scaffolds was:PEEK>Ta>Ti>HA.The number of potential fracture strain elements in tissues around the porous scaffolds was:HA>Ta>PEEK>Ti.Conclusions The HA porous scaffold could not bear the immediate load and guide bone healing well under immediate loading.The elastic modulus of PEEK porous scaffold was similar to that of bone tissues,which could preferably guide bone healing.PEEK was an ideal porous scaffold material under immediate loading.The research findings provide some references for the selection of porous scaffold materials under immediate loading.
作者
喻缇
刘婷
黄元丁
王超
YU Ti;LIU Ting;HUANG Yuanding;WANG Chao(Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,Chongqing Key Laboratory of Oral Diseases and Biomedical Science,Affiliated Stomatological Hospital of Chongqing Medical University,Chongqing 401147,China)
出处
《医用生物力学》
EI
CAS
CSCD
北大核心
2019年第6期615-622,共8页
Journal of Medical Biomechanics
基金
国家自然科学基金面上项目(11872135)
重庆市卫生计生委面上项目(2017MSXML073)
重庆医科大学附属口腔医院科研培育项目(PYM201605)
关键词
多孔支架
医用生物材料
即刻负载
有限元分析
porous scaffold
biomedical materials
immediate loading
finite element analysis(FEA)
