摘要
目的探讨孕中晚期孕妇血清甲胎蛋白(alpha fetoprotein,AFP)及游离β-人绒毛膜促性腺素(human chorionic gonadotropin,HCG)与胎盘缺血性疾病的关系。方法随机选取我院2018年1月至2019年1月产科门诊体检的中晚期孕妇500例,所有孕妇仅行血清AFP及游离β-HCG检测和彩色多普勒检测孕妇胎盘床动脉血流动力,以平均血流速作为胎盘缺血的指标,分析胎盘缺血组和无胎盘缺血组上述血清学指标的差异;并采用Spearmen相关分析方法分析AFP和β-HCG与胎盘平均血流速的相关性。结果胎盘缺血组的血清AFP水平和游离β-HCG水平均明显高于无胎盘缺血组,组间比较差异均具有统计学意义(P<0.05);血流动力学方面:胎盘缺血组的搏动指数和平均血流速度降低,阻力指数增加,与无胎盘缺血组比较差异具有显著性(P<0.05)。相关分析显示,血清AFP及游离β-HCG均与平均血流速度呈负相关(r分别为-0.562,-0.698,P=0.001)。结论随着中晚期孕妇血AFP和游离β-HCG水平升高,胎盘平均血流速度增加,孕妇胎盘缺血的风险随之增加,监测两项指标有助于预测疾病风险。
Objective To investigate the relationship between serum AFP and free HCG in pregnant women with placental ischemic disease.Method Randomly selected from our hospital from January 2018 to January 2019 obstetrics outpatient medical examination of middle-late 500 cases of pregnant women,and all pregnant women only line of serum AFP and free HCG detection and color Doppler detection pregnant placenta bed artery blood flow dynamics,with the average blood flow velocity as indicators of placental ischemia,analysis of placental ischemia and placental ischemia group the serological index difference;Spearmen correlation analysis was used to analyze the correlation between AFP and-hcg and the average blood flow velocity of placenta.Results Serum AFP level and free HCG level in the placental ischemia group were significantly higher than those in the non-placental ischemia group,and the differences between the two groups were statistically significant(P<0.05).Hemodynamics:the pulse index and mean blood flow velocity decreased and the resistance index increased in the placental ischemia group,which was significantly different from that in the non-placental ischemia group(P<0.05).Correlation analysis showed that serum AFP and free HCG were negatively correlated with average blood flow velocity(r=-0.562,-0.698,P=0.001).Conclusions With the increase of blood AFP and free HCG levels,the average blood flow velocity of placenta increases,and the risk of placental ischemia increases in pregnant women.Monitoring the two indicators is helpful to predict the risk of disease.
作者
饶煌珍
RAO Huang-zhen(不详)
出处
《中国产前诊断杂志（电子版）》
2019年第4期70-72,共3页
Chinese Journal of Prenatal Diagnosis(Electronic Version)
关键词
孕妇
甲胎蛋白
游离人绒毛膜促性腺素
胎盘缺血性疾病
Pregnant women
Alpha fetoprotein
Free human chorionic gonadotropin
Placental ischemic disease
