摘要
目的探讨老年男性2型糖尿病(T2DM)患者合并甲状腺结节的临床特征及影响因素。方法选取2017年1月~2018年12月在解放军总医院老年内分泌科门诊就诊的270名老年男性T2DM患者,采用高分辨彩超判断有无甲状腺结节,分为合并甲状腺结节组及无甲状腺结节组,比较两组间临床资料及实验室检查结果的差异,通过logistic回归分析判定相关影响因素。结果老年男性T2DM中合并甲状腺结节患者221例(占81.9%),无甲状腺结节者49例(18.1%)。合并甲状腺结节组体质量指数(BMI)、糖化血红蛋白(HbA1c)和血肌酐明显高于无甲状腺结节者,而高密度脂蛋白(HDL-C)明显低于无甲状腺结节者,差异均有统计学意义(P <0.05)。其他指标如糖尿病病程、吸烟史、合并高血压、甲状腺激素及抗体水平以及甲状腺功能异常(甲亢、亚临床甲亢、甲减、亚临床甲减)的分布差异无统计学意义(P> 0.05)。Logistic回归分析提示,增高的HbA1c和肌酐数值与甲状腺结节发生呈正相关(P <0.05),而降低的HDL-C与之呈负相关(P <0.05)。结论老年男性T2DM患者合并甲状腺结节的发生率为81.9%。HbA1c和血肌酐的升高可能与老年男性T2DM患者甲状腺结节的发生有关。
Objective To investigate the clinical features and related risk factors of thyroid nodule in elderly male patients with type 2 diabetes mellitus(T2 DM). Methods 270 elderly male patients with T2 DM were divided into two groups,one with thyroid nodules and the other without thyroid nodules.Clinical and laboratory examination data were collected for intergroup comparison,which followed by Logistic regression analysis. Results There were 221 elderly male T2 DM patients with thyroid nodules(81.9%)and 49 elderly male T2 DM patients without thyroid nodules.It was found that the body mass index(BMI),glycosylated hemoglobin(HbA1 c)and serum creatinine levels of elderly male T2 DM patients with thyroid nodules were significantly higher than those without thyroid nodules(P < 0.05),while the levels of high-density lipoprotein cholesterol(HDL-C)were significantly lower than those without thyroid nodules(P < 0.05).Other indicators such as diabetes course,smoking history,hypertension,thyroid hormone and antibody levels,and the distribution of four types of thyroid dysfunction(hyperthyroidism,subclinical hyperthyroidism,hypothyroidism,subclinical hypothyroidism)were not statistically significant(P > 0.05).Logistic regression analysis showed that increased HbA1 c and serum creatinine were positively correlated with the occurrence of thyroid nodules(P < 0.05),while decreased HDL-C was negatively correlated with the occurrence of thyroid nodules in elderly male T2 DM patients(P < 0.05). Conclusion The incidence of thyroid nodules in elderly male T2 DM patients is high.HbA1 c and serum creatinine may be associated with thyroid nodules in elderly male T2 DM patients.
作者
李圆园
谷昭艳
李翔
龚燕平
李春霖
Li Yuanyuan;Gu Zhaoyan;Li Xiang(Department of Geriatric Endocrinology,the Second Medical Center of PLA General Hospital,Beijing 100853,China)
出处
《中华保健医学杂志》
2020年第1期5-8,共4页
Chinese Journal of Health Care and Medicine
基金
国家自然科学基金面上项目(81373458)
海南省自然科学基金面上项目(20168350)
