摘要
A ruthenium based catalytic system([Ru(p-cymene)Cl2]2/XantPhos with substoichiometric Cs2CO3)has been established to effectively achieve the first direct amination cyclization of 1,2,4-butanetriol with primary aromatic amines.The product of this sustainable hydrogen autotransfer process is valuable Naryl-3-pyrrolidinol.
A ruthenium based catalytic system（[Ru（p-cymene）Cl2]2/XantPhos with substoichiometric Cs2CO3） has been established to effectively achieve the first direct amination cyclization of 1,2,4-butanetriol with primary aromatic amines.The product of this sustainable hydrogen autotransfer process is valuable Naryl-3-pyrrolidinol.
基金
the National Natural Science Foundation of China (No. 21672027)
QingLan Project of Jiangsu Province (2016)
SixTalent-Peaks Program of Jiangsu (2016) for financial support
supported by High-Level Entrepreneurial Talent Team of Jiangsu Province (No.2017-37)
