摘要
目的观察雾化吸入前列地尔对单肺通气(one lung ventilation,OLV)结束后肺氧合功能的影响。方法择期行右侧开胸食管癌根治术患者42例,按随机数字表法分为实验组(T组)和对照组(C组),每组21例。OLV开始时对左侧肺雾化吸入前列地尔0.2μg/kg(T组)或等量生理盐水(C组)。于0LV前3 min(T1)、0LV结束后3 min(T2),T2后30 min(T3)抽取桡动脉血,行血气分析,根据结果计算氧合指数(oxygenation index,OI)、肺内分流率(pulmonary shunt rate,Qs/Qt)。同时记录各时点血流动力学指标。结果与T1比较,两组患者在T2、T3时OI值下降,Qs/Qt上升,差异有统计学意义(P<0.05);T2T3时T组患者OI值高于C组(P<0.05),Qs/Qt较C组下降(P<0.05);两组患者不同时点血流动力学指标差异无统计学意义(P˃0.05)。结论OLV期间对通气侧肺雾化吸入前列地尔可有效改善0LV结束后肺的氧合功能、减少肺内分流。
Objective To observe the effects of atomizing inhalation of alprostadil on pulmonary oxygenation function after one lung ventilation(OLV).Methods Forty-two patients with thoracic esophageal cancer undergoing elective resection were enrolled in the study and divided into two groups(n=21):a test group(group T)and a control group(group C)according to the random number table.When OLV started,group T received atomizing inhalation of alprostadil 0.2μg/kg via the left lung,while group C received the same amount of normal saline.Radial arterial blood samples were taken 3 min before OLV(T1),3 min after OLV(T2),and 30 min after T2(T3)for blood gas analysis and oxygenation index(OI)and pulmonary shunt rate(Qs/Qt)were calculated.The hemodynamic indexes of the two groups were recorded at these points.Results Patients in both groups presented remarkable decreases in OI values and marked increases in Qs/Qt at T2 and T3 compared with those at T1(P<0.05).Meanwhile,group T showed significantly higher 01 values and lower Qs/Qt at T2 and T3 than group C(P<0.05).There were no significant differences in hemodynamic indexes between the two groups(P˃0.05).Conclusions Atomizing inhalation of alprostadil during OLV towards ventilated lungs can improve oxygenation function and decrease intrapulmonary shunt in patients after OLV.
作者
高清贤
高永涛
尹治青
袁振飞
Gao Qingxian;Gao Yongtao;Yin Zhiqing;Yuan Zhenfei(Department of Anesthesiology,the Fourth Clinical Medical College of Yangzhou University,Nantong Rich Hospital,Nantong 226000,China;Department of Anesthesiology,the Affiliated Hospital of Nantong University,Nantong 226000,China)
出处
《国际麻醉学与复苏杂志》
CAS
2019年第12期1110-1112,共3页
International Journal of Anesthesiology and Resuscitation
关键词
单肺通气
前列地尔
氧合功能
One lung ventilation
Alprostadil
Oxygenation function
