摘要
目的:观察床边血液净化(CBP)对重症病毒性脑病(SVE)患儿的临床疗效。方法:选择本院2016年1月-2019年1月诊断为SVE患儿64例,根据患儿直系家属意愿,同意签署知情同意书者为观察组,否则为对照组,每组各32例。对照组患儿给予常规基础治疗,观察组患儿在对照组基础上给予CBP治疗。比较治疗前、治疗7 d后两组患儿病情状况[急性生理功能和慢性健康状况评分系统Ⅱ(APACHEⅡ)、格拉斯哥昏迷指数(GCS)]、脑脊液指标[白细胞(WBC)、蛋白量]、炎症因子[血清白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]检测水平。结果:治疗7 d后,两组患儿GCS评分较治疗前显著升高(P均<0.05),且观察组明显高于对照组(P均<0.05),两组患儿APACHEⅡ、脑脊液各指标、炎症因子各指标水平均较治疗前显著降低(P均<0.05),且观察组均明显低于对照组(P均<0.05)。结论:CBP具有较好的临床疗效,能改善SVE患儿的症状,减轻体内炎症反应,对患儿预后康复有利。
Objective:To observe the clinical efficacy of continuous bedside blood purification(CBP)in children patients with severe viral encephalopathy(SVE).Methods:Sixty four children patients diagnosed as SVE from January 2016 to January 2019 in the hospital were selected.According to the will of immediate family members of children patient,those who agreed to sign the informed consent form were set as observation group,otherwise they were included in control group,with 32 cases in each group.Control group was given routine basic therapy,and observation group was given CBP on the basis of control group.The disease status[Acute Physiological and Chronic Health EvaluationⅡ(APACHEⅡ),Glasgow Coma Scale(GCS)],cerebrospinal fluid indexes[white blood cells(WBC),protein amount]and inflammatory factors[serum interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)]were compared between the two groups before treatment and after 7d of treatment.Results:After 7d of treatment,the GCS scores of children patients in the two groups were significantly higher than those before treatment(all P<0.05),and the score in observation group was significantly higher than that in control group(all P<0.05).The APACHEⅡ,cerebrospinal fluid indexes and inflammatory factors of children patients in the two groups were significantly lower than those before treatment(all P<0.05),and the above indexes in observation group were significantly lower than those in control group(all P<0.05).Conclusions:CBP has a good clinical efficacy,and can improve the symptoms and reduce the inflammatory response in vivo of children patients with SVE,and it is beneficial to the prognosis and rehabilitation of children patients.
作者
吴志扬
蒲榕
WU Zhi-yang;PU Rong(Department of Intensive Care,Quanzhou Children's Hospital,Quanzhou,Fujian 362000)
出处
《赣南医学院学报》
2020年第1期72-75,共4页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
血液净化
病毒性脑病
炎症因子
Blood purification
Viral encephalopathy
Inflammatory factors
