摘要
Krüppel样因子5(KLF 5)属于含锌指的转录因子家族,参与调控多种基因的表达,从而影响细胞的多种功能。如干细胞自我更新、细胞增殖、分化和凋亡。KLF 5作为一种重要的转录因子和潜在的药物靶点受到了越来越多的关注。在这篇综述中,我们阐述了KLF 5和KLF家族的特点及其在相关肿瘤中的研究进展。
Krüppel like factor 5(KLF 5)belongs to the family of transcription factors containing zinc finger and is involved in the regulation of the expression of multiple genes,thereby affecting the multiple functions of cells,such as stem cells self-renewal,cell proliferation,differentiation and apoptosis.KLF 5 has received increasing attention as an important transcription factor and potential drug target.In this review,we describe the characteristics of the KLF5 and KLF families and their progress in related tumors.
作者
秦海丹
赵艳滨
王艳
Qin Haidan;Zhao Yanbin;Wang Yan(Department of Medical Oncology,the Affiliated Tumor Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China)
出处
《现代肿瘤医学》
CAS
2020年第6期1036-1039,共4页
Journal of Modern Oncology
