摘要
目的:探讨亮丙瑞林微球蛋白在子宫肌瘤术前应用的临床效果。方法:选取本院拟实施腹腔镜子宫肌瘤剔除术患者160例,根据就诊顺序分为观察组和对照组各80例,观察组术前给予亮丙瑞林微球蛋白治疗3个月后实施手术、术后继续使用亮丙瑞林微球蛋白维持治疗1个月,对照组直接实施手术;对比两组血清雌激素(E 2)、孕激素(P)、促卵泡刺激素(FSH)、促黄体生成素(LH)水平,手术情况及术后12、24个月子宫肌瘤复发率。结果:血清E 2、P、FSH、LH水平术后3个月两组均较术前不同程度降低,且术前及术后3个月观察组均低于对照组(P<0.05);观察组术中出血量(88.1±15.0ml)低于对照组(100.5±18.5ml)(P<0.05),手术时间、术后下床活动时间、住院时间与对照组无差异(P>0.05);术后24个月子宫肌瘤复发率,观察组无,对照组有4例(5.0%),对照组高于观察组(P<0.05)。结论:亮丙瑞林微球蛋白在子宫肌瘤手术前应用能进一步降低相关性激素水平,减少手术中出血量,降低术后子宫肌瘤复发率。
Objective:To investigate the clinical effect of leuprolide microglobulused before and after hysteromyomectomy for preventing uterine fibroids recurrence.Methods:160 patients who had experinced laparoscopic hysteromyomectomy were selected and were divided into observation group and control group according to the order of treatment.The patients in the observation group were given leuprolide microglobulin for 3 months before hysteromyomectomy and for 1 month after operation.The patients in the control group were not given leuprolide microglobulin before and after operation.The levels of serum E 2,P,FSH and LH,the operation situation,and the recurrence rate of uterine fibroids in 12 months and 24 months after operation of patients were compared between the two groups.Results:The serum E 2,P,FSH and LH levels of patients in both groups had decreased significantly in 3 months after operation(P<0.05).Before and 3 months after operation,the levels of serum E 2,P,FSH and LH of patients in the observation group were significant lower than those of of patients in the control group(P<0.05).The amount of intraoperative blood loss of patients in the observation group was 88.1±15.0ml,which was signifficant lower than that(100.5±18.5ml)of patients in the control group(P<0.05).There was no signifficant different in the operation time,the time out of bed for activity after operation,and the time of hospital stay of patients between the two groups(P>0.05).Conclusion:The application of leuprolide microglobulin before hysteromyomectomy can further reduce the levels of sex hormones of patients,reduce the amount of bleeding during operation,and can decrease the recurrence rate of postoperative uterine fibroids.
作者
李晟辉
骆黎静
周琦
LI Yuhui;LUO Lijing;ZHOU Qi(Beijing Maternity Hospital,Capital Medical University,Beijing,100026)
出处
《中国计划生育学杂志》
2020年第2期261-263,267,共4页
Chinese Journal of Family Planning
关键词
子宫肌瘤术
亮丙瑞林微球蛋白
围术期
性激素
复发
Hysteromyomectomy
Leuprolide microglobulin
Perilperative period
Sex hormones
Recurrence
