摘要
目的:对比盐酸纳美芬和盐酸纳洛酮在急性重度酒精中毒中的疗效,为临床用药提供参考.方法:选取笔者所在医院2018年3月-2019年3月90例急性重度酒精中毒患者,根据所用药物不同分为试验组和对照组,各45例.两组均进行常规治疗,在此基础上试验组给予盐酸纳美芬,对照组给予盐酸纳洛酮.观察两组中毒症状消失时间、意识清醒时间等.结果:试验组意识清醒时间及中毒症状消失时间均早于对照组,不良反应发生率少于对照组,总有效率高于对照组,差异均有统计学意义(P<0.05).结论:相比盐酸纳洛酮,盐酸纳美芬可明显提升急性重度酒精中毒患者的治疗效果,能够缩短中毒症状消失时间,且安全性较高,可作为治疗急性重度酒精中毒首选药物.
Objective:To compare the efficacy of Naloxone Hydrochloride and Nalmefene Hydrochloride in acute severe alcoholism,so as to provide a reference for clinical use.Method:A total of 90 cases of acute severe alcoholism in our hospital from March 2018 to March 2019 were divided into the experimental group and the control group according to the different drugs used,45 cases in each group.Both groups were given routine treatment.On this basis,the experimental group received Nalmefene Hydrochloride and the control group received Naloxone Hydrochloride.The time of disappearance of poisoning symptoms and the time of conscious awake were observed between the two groups.Result:The time of conscious awake and the time of disappearance of poisoning symptoms in the experimental group were earlier than those of the control group,and the incidence of adverse reactions was less than that of the control group,and the total effective rate was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion:Compared with Naloxone Hydrochloride,Nalmefene Hydrochloride can significantly improve the efficacy of acute severe alcoholism,shorten the time of disappearance of poisoning symptoms.It has a high safety and can be used as the first choice for the treatment of acute severe alcoholism.
作者
刘丽英
陈瑶
LIU Liying;CHEN Yao(Qujing First People’s Hospital,Qujing 655000,China)
出处
《中外医学研究》
2020年第2期159-161,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
盐酸纳美芬
盐酸纳洛酮
急性重度酒精中毒
疗效
Nalmefene Hydrochloride
Naloxone Hydrochloride
Acute severe alcoholism
Curative effect
