摘要
分析探究在孕晚期阶段感染B族链球菌患者应用头孢曲松钠治疗对其感染状态及母婴传播的影响水平变化及其临床意义。以该院于2017年1月~2018年6月收治的310例B族链球菌感染患者为研究对象,将其随机分为两组,研究组155例,对照组155例。其中,对照组采用青霉素治疗,研究组采用头孢曲松钠联合青霉素进行治疗。两组持续治疗至妊娠结束后进行治疗效果统计与评价。通过治疗,两组患者IL-6、PCT两项指标水平显著下降,最终研究组各项指标水平明显低于对照组,两组数据相比较,差异具有统计学意义(P <0. 05)。统计310例患者妊娠结局发现,对照组早产、胎膜早破、羊膜腔感染、子宫内膜炎、产褥感染等事件总发生率为19. 35%,研究组此类事件总发生率为5. 81%,对照组此类事件总发生率显著高于研究组,两组数据相比较,差异具有统计学意义(x2=12. 935,P <0. 001)。统计新生儿健康情况发现,研究组中毒性休克、肺炎、败血症、脑膜炎总发生率为5. 16%,对照组此类事件总发生率为18. 06%,对照组总发生率远高于研究组,两组数据相比较,差异具有统计学意义(x2=12. 571,P <0. 001)。治疗期间,两组均有不良反应发生,其中,研究组不良反应总发生率为8. 39%,低于对照组不良反应总发生率为9. 68%,两组数据相比较,差异无统计学意义(x2=0. 157,P=0. 692)。头孢曲松钠用于B族链球菌感染的孕妇孕晚期治疗能有效降低相关炎症因子水平,改善患者感染状态和新生儿健康状态,具有较低的临床风险性和较好的临床使用价值。
To analyze and explore the effect of ceftriaxone sodium on infection status and mother to child transmission in patients infected with group B streptococcus in the late pregnancy stage and its clinical significance,310 cases of B streptococcal infection in the author’s hospital from January 2017 to June 2018 were studied. They were randomly divided into two groups,155 cases in study group and 155 cases in control group. Among them,the control group were treated with penicillin,and the study group were treated with ceftriaxone sodium combined with penicillin. The two groups were treated with continuous treatment until the end of pregnancy and they also evaluated the therapeutic effects. This study found that through treatment,the levles of IL-6 and PCT of the two groups were decreased significantly,and the indexes of study group were significantly lower than those of control group. The difference between the two sets of data was statistically significant( P < 0. 05). The total incidence of preterm birth,premature rupture of membranes,amniotic cavity infection,endometritis,puerperium infection and other events of control group was 19. 35%,while the total incidence of such events of study group was 5. 81%. The incidence of such events of control group was significantly higher than that of study group,and the difference between the two groups was statistically significant( x2= 12. 935,P < 0. 001). The overall incidence of toxic shock,pneumonia,septicemia and meningitis of study group was 5. 16%,and the total incidence of such events of control group was 18. 06%. The total incidence of the control group was much higher than that of the study group. The difference between the two sets of data was statistically significant( x2= 12. 571,P < 0. 001). During the treatment,adverse reactions occurred in the two groups. The total adverse reaction rate of the study group was 8. 39%. And the total incidence of adverse reactions of control group was 9. 68%,which was higher than that of the study group. The difference between the two sets of data was not statistically significant( x2= 0. 157,P = 0. 692). Ceftriaxone sodium used for patients infected with group B streptococcus in the late pregnancy stage can effectively reduce the levels of related inflammatory factors. It can also improve the patients’ infection state and the health of the newborn. This therapeutic method has low clinical risk and a good clinical value.
作者
岳华
郭金珠
吕鑫荣
YUE Hua;GUO Jin-zhu;LYU Xin-rong(Department of Obstetrics and Gynecology,Xidian Group Hospital,Xi'an 710068,China)
出处
《药物生物技术》
CAS
2019年第6期537-540,共4页
Pharmaceutical Biotechnology
关键词
孕晚期
头孢曲松钠
B族链球菌
母婴传播
感染状态
Late pregnancy stage
Ceftriaxone sodium
Group B streptococcus
Mother to child transmission
Infection status
