摘要
增龄性肌肉衰减症(sarcopenia)和骨质疏松症(osteoporosis,OP)等疾病以及意外引发的肌肉、骨骼急性损伤性疾病严重影响人们的生活质量。人体是一个有机整体,骨骼和肌肉共同构成运动系统,在遗传背景、生理和病理上存在紧密联系,且共同接受外界环境变化对机体产生的影响。肌骨系统的概念建立以来,大量研究表明,除机械力学转导外,骨骼和肌肉作为内分泌器官能够在分子水平上互相影响,这为解决“肌少-骨质疏松症”提供了新的思路。骨骼源性因子是由骨组织细胞分泌的活性因子与多肽。近年来,骨骼肌通过分泌“肌肉因子”在肌骨系统中扮演的重要角色受到科学领域的关注,而对于骨骼源性因子如何影响肌肉功能知之甚少。以肌骨“Crosstalk”为切入点,全面了解骨骼源性OCN、Wnt3a、PGE 2、IGF-1、MGF、VEGF和HGF等因子介导骨骼肌代谢和功能变化的可能机制,有助于筛选出骨骼源性因子作为肌肉骨骼疾病的治疗靶点,促进新兴药物的开发,对于探究肌骨疾病的新兴治疗手段具有重大意义。
Diseases such as age-related sarcopenia and osteoporosis as well as acute musculoskeletal injuries caused by accidents seriously affect people's quality of life.The human body is an organic integrity.Bone and muscle constitute the locomotor system together.They are closely related in genetic background,physiology and pathology,and are influenced by the change of external environment.Since the concept of musculoskeletal system was established,a large number of studies have shown that,in addition to mechanical transduction,bone and muscle as endocrine organs can interact on the molecular level,which provides a new idea for the solution of“sarco-osteopenia”.Bone-derived factors are active factors and polypeptides secreted by bone cells.In recent years,the important role of skeletal muscle in the musculoskeletal system through the secretion of“myokines”has attracted attention in the scientific field.However,little is known about how bone-derived factors affect muscle function.Taking the musculoskeletal“crosstalk”as the entry point and understanding the possible mechanisms of bone-derived OCN,Wnt3a,PGE 2,IGF-1,MGF,VEGF,HGF,and other factors that mediate skeletal muscle metabolism and function changes may help to screen out bone-derived factors as therapeutic targets for musculoskeletal diseases and to promote the development of emerging drugs,which is of great significance for exploring new therapeutic method for musculoskeletal diseases.
作者
宗博艺
李世昌
孙朋
袁子琪
ZONG Boyi;LI Shichang;SUN Peng;YUAN Ziqi(Key Laboratory of“Evaluating and Sports Intervening to Adolescent’s Health”of Ministry of Education/School of Physical Education and Health Care,East China Normal University,Shanghai 200241,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2020年第1期118-123,共6页
Chinese Journal of Osteoporosis
基金
教育部重点实验室项目(40500-541235-14203/004)
关键词
骨骼源性因子
骨骼
骨骼肌
肌骨疾病
骨质疏松
bone-derived factors
bone
skeletal muscle
musculoskeletal disorders
osteoporosis
