摘要
背景:牙种植区域的牙槽骨骨量不足增加了种植手术难度,植骨材料的出现成功解决了此类难题。在所有单一植骨材料中,异种煅烧骨被广泛用于治疗骨缺损,但单独使用煅烧骨时仍然存在一些缺点。目的:结合最新的相关研究动态,对异种煅烧骨材料修复骨缺损的相关研究进展作以综述。方法:第一作者以"calcined bone,xenogeneic bone,bone augmentation,bone substitute"为英文检索词,以"煅烧骨、异种骨、骨增量、骨替代材料"为中文检索词,应用计算机检索PubMed、维普、万方、知网数据库中1986年1月至2019年11月已发表的相关文献,并进行筛选、归纳与总结,最终纳入69篇相关文献进行综述。结果与结论:在所有骨移植材料中,异种煅烧骨的结构与人类骨骼相似,具有良好的互连孔性,便于血管因子和骨原细胞进入,为新骨形成提供了通道和支架作用,同时具有良好的生物相容性及一定的降解作用,受到临床医生们的青睐。但其本身仍然存在溶解度较低、吸收缓慢、机械性能较差等不足,这就促使研究者们研发出将煅烧骨与陶瓷、聚合物、骨诱导因子及金属离子等其他材料复合,发挥出所参与材料的优点,从而使复合材料成为骨增量材料的首选。
BACKGROUND: Insufficient alveolar bone volume in the dental implant area increases the difficulty of implant surgery, and the emergence of bone graft materials has successfully solved such problems. Among all single bone graft materials, xenogeneic calcined bone is widely used for the treatment of bone defects. However, there are still some disadvantages when using calcined bone alone. OBJECTIVE: To review the research progress in the repair of bone defects by heterogeneous calcined bone materials based on the latest relevant research trends. METHODS: The first author searched PubMed, VIP, WanFang and CNKI databases for relevant articles published from January 1986 to November 2019. The search terms were "calcined bone, xenogeneic bone, bone augmentation, bone substitute" in English and Chinese, respectively. Finally, 69 eligible articles were included for result analysis. RESULTS AND CONCLUSION: In all bone graft materials, calcined xenogeneic bone has good interconnectivity due to its similar characteristics to human bone structure. It facilitates the entry of vascular factors and osteogenic cells, provides channels and scaffolding for new bone formation, and has good biocompatibility and certain degradation, so it is preferred by surgeons. However, there are still some shortcomings, such as low solubility, slow absorption and poor mechanical property, which prompt researchers to develop a composite of calcined bone with ceramics, polymer, osteoinductive factor and metal ion. This can utilize the advantages of the involved materials, and thus the composite becomes a first choice of bone increment.
作者
李芳
伍超
石前会
程余婷
周倩
霍花
齐昱晗
董强
廖健
Li Fang;Wu Chao;Shi Qianhui;Cheng Yuting;Zhou Qian;Huo Hua;Qi Yuhan;Dong Qiang;Liao Jian(School/Hospital of Stomatology of Guizhou Medical University,Guiyang 550004,Guizhou Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2020年第16期2592-2598,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金(81660179)，项目负责人：廖健
贵州省科技计划项目(黔科合LH [2016]7257)，项目负责人：廖健~~
关键词
煅烧骨
异种骨
骨移植
骨增量
骨缺损
骨替代材料
复合材料
组织工程
calcined bone
xenogenic bone
bone graft
bone increment
bone defect
bone substitute material
composite
tissue engineering
