摘要
本共识针对近年来研究结果较为明确的肝胆肿瘤相关蛋白质、基因表达层面的分子标志物在诊断、治疗、分子分型方面的研究进展及临床应用指导意义等做了详尽的总结,提出了专家指导意见。同时对肝胆肿瘤相关血清学、组织病理学、二代测序等实验室检测的标准、结果判读、报告内容及全过程质量管理等提出了规范化的建议,旨在为一线临床工作人员普及肝胆肿瘤分子诊疗最新知识,并提供科学、合理选择个体化精准诊疗方案的可执行依据。
In hepatobiliary carcinoma, serologic and histologic biomarkers including proteins andgenes have been recommended and categorized for cancer diagnosis,targeted therapy and immunotherapyregimen selection, as well as prognostic prediction at different levels. To standardize the application ofmolecular biomarkers in clinical diagnosis , therapeutic evaluation, and prognosis prediction of primary hepa-tobiliary carcinoma , we summarized the current well studies biomarkers with clinical significance in both ser-um and tumor tissue as well as provided professional agreements on their potential utilization in this consen-sus. Moreover, we have made recommendations on standards for laboratory detection, technical operation,data analysis, result interpretation, clinical report ,and the whole-process quality management in serological,histopathological detection and next-generation sequencing. According to these, we aim to offer clinical staffswith scientific and practical references and guidance to achieve better personalized treatment decisions fromthese up-to-date knowledges of molecular diagnosis on hepatobiliary carcinoma.
作者
无
陆荫英
赵海涛
程家敏
姬峻芳
无;Lu Yinying(Society for Hepatobiliary,Medical Sociey of Western Retuned Scholars Assosiption;Sociely for Molecular Diagnosis,Chinese Research Hospital Association;Expert Committee for Liver Cancer,Chinese Society of Clinical Oncology;Professional Committee for the Prevention and Control of Hepatobiliary and Pancreatic Diseases,Chinese Preventive Medicine Association;Expert Comite for Liver Cancer,Asia Paific Alliance of Liver Diseases;The Comprehensive Liver Cancer Center,the 5th Medical Center of PLA General Hospital,Beijing 100039,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2020年第2期81-89,共9页
Chinese Journal of Hepatobiliary Surgery
基金
精准医学国家重点专项计划(2017YFC0908401)
“十三五”国家科技(传染病)重大专项课题(2018ZX10723204007-002,2018ZX10302205-001)。
关键词
肝脏肿瘤
胆道肿瘤
分子标志物
临床诊断
疗效评估
靶向治疗
免疫治疗
专家共识
Hepatobiliary carcinoma
Biliary tract neoplasm
Biomarker
Clinical diagnosis
Effect evaluation
Targeted therapy
Immunotherapy
Expert consensus
