摘要
目的探讨无创高频振荡通气和经鼻间歇正压通气在治疗新生儿呼吸衰竭中的有效性和安全性。方法以该院2016年9月至2018年6月收治的124例呼吸衰竭新生儿作为研究对象,根据无创通气方法的不同分为无创高频振荡通气(n HFOV)组(58例)和经鼻间歇正压通气(NIPPV)组(66例),对两组患儿无创通气后12 h内的动脉血气指标、治疗过程中并发症的发生情况及临床效果进行比较分析。结果两组患儿出生即刻pH值、动脉血二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)以及氧合指数(OI)水平差异均无统计学意义(P>0.05),给予无创机械通气后1 h后nHFOV组PaCO2水平相比NIPPV组明显降低,OI相比NIPPV组明显增高(P<0.05);通气3h后nHFOV组PaCO2水平明显低于NIPPV组(P<0.05);通气12 h后两组患儿各项指标差异均无统计学意义(P>0.05)。通气过程中,nHFOV组患儿低氧血症、高碳酸血症的发生率相比NIPPV组明显减少(P<0.05)。结论经鼻间歇正压通气和无创高频振荡通气均可有效改善新生儿呼吸衰竭,在提高患儿的肺氧合能力方面均具有显著效果,但无创高频振荡通气在改善通气功能方面更加具有优势。
【Objective】To explore the efficacy and safety of noninvasive high frequency oscillatory ventilation(nHFOV)and nasal intermittent positive pressure ventilation(NIPPV)in the treatment of respiratory failure in premature infants.【Methods】A total of 124 cases of premature infants with respiratory failure treated in our hospital from September 2016 to June 2018 were selected as the research objects,according to the different methods of noninvasive ventilation were divided into nHFOV group(58 cases)and NIPPV group(66 cases),then the index of blood gas in 12 h of children with noninvasive ventilation,complications occurred in the process and the treatment effect of two groups were compared and analyzed.【Results】The levels of the immediate pH,PaCO2,PaO2 and OI at the time of birth were not significantly different between the two groups(P>0.05).After 1 h of noninvasive mechanical ventilation,the PaCO2 level in the nHFOV group was significantly lower than that in the NIPPV group,and the level of OI was significantly higher than that in the NIPPV group(P<0.05).After ventilation for 3 h,the PaCO2 level in the nHFOV group was significantly lower than that in the NIPPV group(P<0.05).After 12 h of ventilation,there was no significant difference in the indexes between the two groups(P>0.05).During the ventilation,the incidence of hypoxemia and hypercapnia in the nHFOV group was significantly lower than that in the NIPPV group(P<0.05).【Conclusion】Both intermittent positive pressure ventilation through the nose and non-invasive high-frequency oscillatory ventilation can effectively improve respiratory failure in premature infants,and had significant effects in improving the lung oxygenation capacity of children,but non-invasive high-frequency oscillatory ventilation had more advantages in improving ventilation function.
作者
陈霞
CHEN Xia(Neonatology Department,Tanghe County People's Hospital,Nanyang,Henan 473400,China)
出处
《中国医学工程》
2019年第10期21-24,共4页
China Medical Engineering
关键词
早产儿
呼吸衰竭
有效性
安全性
premature infants
respiratory failure
effectiveness
security
