摘要
目的:系统评价针刺治疗乳腺增生病的疗效与安全性。方法:系统检索四大中文数据库(CNKI、WanFang、VIP、SinoMed)和英文数据库(Medline、Cochrane Library),时间为各数据库建库至2018年12月,并辅以手工检索,纳入针刺治疗乳腺增生随机对照试验研究。由两名评价者独立筛选文献、交叉核对,评估偏倚风险,采用Review Manager5.3软件进行Meta分析。结果:纳入15项随机对照试验,涉及1588例患者。针刺+中药组治疗优于中药组治疗,针刺+西药组治疗优于西药组治疗,其他结局指标受各方面因素的影响(如结局指标间异质性太大等)而无法得出结论。结论:基于本研究结果,针刺治疗乳腺增生病有一定的疗效,且未见严重不良反应发生。但由于受到纳入研究数量及质量限制,致使本研究结果证据质量较低,故在运用该结论时需谨慎。针刺治疗乳腺增生病疗效和安全性还有待今后开展设计合理、实施严谨、报告规范的多中心大样本随机双盲对照试验来验证。
Objective: To evaluate the efficacy and safety of acupuncture for mammary gland hyperplasia.Methods: Randomized controlled trials were searched among four Chinese databases(CNKI, VIP, WanFang,SinoMed) and English databases(Cochrane Library, Medline) on acupuncture for mammary gland hyperplasia. The retrieval time was from the establishment of each database to December 2018. Two evaluators independently screened the literature, cross-checked and assessed the risk of bias. Meta-analysis was performed by using Review Manager 5.3 software. Results: 15 RCTs involving 1588 patients were included. The treatment of acupuncture and Chinese medicine group was better than that of traditional Chinese medicine group. The treatment of acupuncture and western medicine group was better than that of western medicine group.Conclusion: Based on the results of this study, it has been shown that acupuncture has a certain effect on the treatment of mammary gland hyperplasia, and no serious adverse reactions have occurred. However, due to the limited number and quality of the included studies, the quality of the evidence in this study is of low quality,so caution should be exercised when applying this conclusion. And more high quality multicenter randomized double-blind controlled trials are needed to verify.
作者
王子彦
李彩彩
尹业辉
王少军
WANG Zi-yan;LI Cai-cai;YIN Ye-hui;WANG Shao-jun(Acupuncture Hospital of Chinese Academy of Traditional Chinese Medicine,Beijing 100700,China)
出处
《中医药导报》
2020年第2期86-90,共5页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词
乳腺增生
随机对照试验
针刺
系统评价
疗效
安全性
mammary gland hyperplasia
randomized controlled trial
acupuncture
system evaluation
efficacy
safety
