摘要
目的应用三维超声评估米非司酮对低危型瘢痕妊娠(CSP)的治疗疗效。方法选取经我院超声量化评分系统评分<5分的CSP患者29例(CSP组)和同期瘢痕子宫宫内妊娠(IUP)患者25例(IUP组),应用三维超声监测两组患者口服米非司酮前后孕囊周边的血管指数(VI)、血流指数(FI)及血管血流指数(VFI)的变化,以及VI差值、FI差值及VFI差值情况[即VI差值=VI(前)-VI(后),FI差值=FI(前)-FI(后),VFI差值=VFI(前)-VFI(后)]。结果CSP组和IUP组服用米非司酮2 d后孕囊周边VI和VFI均较用药前明显降低,差异均有统计学意义(均P<0.05);CSP组:VI差值(3.34%±2.64%)、FI差值(1.45±4.31)、VFI差值(1.80±1.46);IUP组:VI差值(2.37±2.29%)、FI差值(0.92±4.94)、VFI差值(1.25±1.28),两组患者米非司酮治疗前后比较差异均无统计学意义;且两组患者的总有效率比较差异无统计学意义。结论通过三维超声对米非司酮治疗超声量化评分系统评分<5分的CSP患者的疗效监测,认为该类CSP患者可行常规的药物流产联合清宫术达到治疗目的。
Objective To evaluate the effect of mifepristone in the treatment of low-risk cesarean scar pregnancy(CSP)by three-dimensional ultrasound.MethodsTwenty-nine patients with CSP whose systemic score was less than 5(CSPgroup),and 25 patients with scar intrauterine pregnancy(IUP group)were included.Three-dimensional ultrasound was used tomonitor changes in vascular index(VI),blood flow index(FI),and vascular blood flow index(VFI),as well as VI difference,FIdifference,and VFI difference around the gestational sac before and after oral administration of mifepristone[ie VI difference=VI(front)-VI(rear),FI difference=FI(front)-FI(rear),VFI difference=VFI(front)-VFI(rear)].ResultsThe VI and VFIaround the gestational sac of the CSP group and the IUP group after taking mifepristone for 2 d were significantly lower thanbefore administration,and the differences were statistically significant(both P<0.05).VI,FI,VFI of CSP group and IUP groupwere(3.34%±2.64%)vs.(2.37%±2.29%),(1.45±4.31)vs.(0.92±4.94),(1.80±1.46)vs.(1.25±1.28),respectively.Therewere no significant difference of these indicators between the two groups before and after treatment with mifepristone.And therewas no significant difference in the total effective rate between the two groups.ConclusionThree-dimensional ultrasound isused to monitor the effect of mifepristone in CSP patients with ultrasound quantitativ score less than 5.It is considered thatroutine drug abortion combined with uterine curettage is effective for CSP patients.
作者
张启源
李素芬
高春燕
张玥
田红菊
颜苹
陈正琼
熊希
ZHANG Qiyuan;LI Sufen;GAO Chunyan;ZHANG Yue;TIAN Hongju;YAN Ping;CHEN Zhengqiong;XIONG Xi(Department of Obstetrics and Gynecology,the Second Clinical Medical College of Army Medical University,Chongqing 400037,China)
出处
《临床超声医学杂志》
CSCD
2020年第3期225-228,共4页
Journal of Clinical Ultrasound in Medicine
基金
陆军军医大学第二附属医院科研项目(2016YLC23、2016YLC28)
重庆市科卫联合重点项目(2018ZDXM034)。
关键词
超声检查
三维
米非司酮
瘢痕妊娠
低危型
超声量化评分系统
Ultrasonography,three-dimensional
Mifepristone
Cesarean scar pregnancy,low-risk
Ultrasound quantitative score system
