摘要
目的探究氢吗啡酮超前镇痛对股骨骨折患者舒芬太尼用量及炎性因子影响。方法以我院2018年1月-2019年12月收治的80例股骨骨折患者为研究对象,按照随机双盲法,分为实验组和对照组。对照组于切皮前15min注射生理盐水10ml,实验组于切皮前15min静脉注射氢吗啡酮10μg/kg。随后两组患者给予相同的麻醉诱导和麻醉维持方案。术毕给予舒芬太尼自控镇痛。比较两组患者舒芬太尼用量及炎性因子变化情况。结果术后48h内实验组的镇痛按压次数、舒芬太尼总用量均低于对照组(P<0.05),其术后1h、术后24h的IL-6、TNF-α、S100β蛋白浓度及VAS评分均低于对照组(P<0.05),而两组患者术后1h、术后24h的Ramsay镇静评分相比,差异无统计学意义(P>0.05)。结论氢吗啡酮超前镇痛可显著降低股骨骨折患者舒芬太尼用量及炎性因子水平,镇痛效果较好,值得推广。
Objective To investigate the effect of preemptive analgesia with hydromorphone on the sufentanil and inflammatory factors in patients with femoral fracture.Methods 80 patients with femoral fracture admitted to our hospital from January 2018 to October 2019 were selected as the study objects,and divided into experimental group and control group according to the randomized double-blind method.In the control group,10ml of normal saline was injected 15 minutes before skin cutting,and in the experimental group,10μg/kg of hydromorphone was injected intravenously 15 minutes before skin cutting.Then the two groups were given the same anesthesia induction and maintenance program.After the operation,sufentanil was given for patient-controlled analgesia.The dosage of anesthetic and the change of inflammatory factors were compared between the two groups.Results Within 48 hours after operation,the number of times of analgesic pressing and the total sufentanil in the experimental group were lower than those in the control group(P<0.05).The concentrations of IL-6,TNF-α,S100βprotein and the VAS scores in the experimental group were lower than those in the control group(P<0.05),but there was no significant difference in Ramsay Sedation scores in the two groups(P>0.05).Conclusion Hyperpreemptive analgesia with hydromorphone can significantly reduce the sufentanil and the level of inflammatory factors in patients with femoral fracture,and has good analgesic effect,which is worth popularizing.
作者
胡凯
程平平
王城
喻惠芬
Hu Kai;Cheng Pingping;Wang Cheng;Yu Huifen(Department of Anesthesiology,Nanchang Hongdu Hospital of traditional Chinese MedicineNanchangJiangxi330006,China)
出处
《江西医药》
CAS
2020年第3期253-255,共3页
Jiangxi Medical Journal
基金
江西省卫生健康委员会科技计划项目,编号20204089。
关键词
股骨骨折
氢吗啡酮
超前镇痛
舒芬太尼
炎性因子
Femoral fracture
Hydromorphone
Preemptive analgesia
sufentanil
Inflammatory factors
