摘要
沙门氏杆菌是一种重要的人兽共患病原菌,食用被沙门氏杆菌污染的家禽产品是人类感染沙门氏杆菌的主要原因。研究家禽抗沙门氏杆菌感染的免疫应答机制对控制沙门氏杆菌在家禽和食物链中的传播具有重要意义。感染早期,机体利用固有免疫系统抵抗沙门氏杆菌的感染,然而其在体内的完全清除依赖于适应性免疫应答,其中CD_4^+、CD_8^+、γδT细胞和B细胞等发挥重要作用。文章对家禽抗沙门氏杆菌感染的固有免疫和适应性免疫应答研究进展进行了总结,并重点阐述了T细胞和B细胞的作用,以期为家禽沙门氏杆菌病的防控提供新的思路。
Salmonella is an important zoonotic pathogen.Eating poultry products contaminated with Salmonella is an important cause of human infection with Salmonella.The consumption of poultry products contaminated with Salmonella is the main cause of human infection with Salmonella.Studying the immune response mechanism of poultry against Salmonella infection is important for controlling the spread of Salmonella in poultry and food chains.In the early stage of infection,the innate immune system is used to resist Salmonella infection in the body.However,its complete clearance in vivo depends on the adaptive immune response,in which CD4+,CD8+,γδT and B lymphocytes play an important role.This review summarizes the innate immunity and adaptive immunity of poultry against Salmonella infection,especially the role of T and B lymphocytes in order to provide new ideas for the prevention and control of salmonellosis in poultry.
作者
唐娟
康喜龙
胡茂志
焦新安
潘志明
TANG Juan;KANG Xilong;HU Maozhi;JIAO Xinan;PAN Zhiming(Jiangsu Provincial Key Laboratory of ZcMinosis,Yangzhou University,Yangzhou 225009,China;Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou University,Yangzhou 225009,China;Key laboratory of Prevention and Control of Miological Hazard Faclors(Animal Origin)for Agrifood Safety and Quality in the Minisln of Agriculture and Rural Agriculture,Yangzhou University,Yangzhou 225009,China;Joinl Laboratory of International C(M>peration in Agriculture and Agricultural Products Safety,Yangzhou University,Yangzhou 225009,China)
出处
《黑龙江畜牧兽医》
CAS
北大核心
2020年第1期36-40,共5页
Heilongjiang Animal Science And veterinary Medicine
基金
国家重点研发计划项目(2016YFD0501607)
公益性行业(农业)科研专项(201403054)
国家自然科学基金项目(31320103907)
江苏省高校优势学科建设工程资助项目(PAPD)
扬州大学科技创新团队项目(2016)。
