摘要
高原环境会影响药物在体内的代谢,使得药动学参数、药物代谢酶及转运体的表达及功能均会发生变化。随着医药行业的快速发展,治疗药物监测(TDM)作为个体化用药的依据被广泛的关注,高原环境对监测药物有何影响?笔者通过查阅国内外相关文献,对临床上常用的治疗监测药物种类、治疗窗以及检测血样进行了归纳和总结,分析高原低氧环境对临床常用监测药物代谢的影响。为高原临床治疗药物监测提供参考,更好的保证高原人群合理用药,也为后期课题组开展高原治疗药物监测以及研究药物的遴选提供参考。
Plateau environment will affect the metabolism of drugs in the body, which will cause changes in pharmacokinetic parameters, expression and function of drug metabolizing enzymes and transporters. With the rapid development of the pharmaceutical industry, therapeutic drug monitoring(TDM) has been widely paid attention to as a basis for personalized drugs.What impact does the plateau environment on monitoring drugs? In this literature review, we will summarize the types of commonly used therapeutic monitoring drugs, therapeutic windows, and blood samples, analyze the effects of plateau hypoxic environment on the metabolism of commonly used monitoring drugs, provide a reference for the clinical treatment and monitoring drugs of plateau,better ensure the rational use of drugs in the plateau population, and also provide a reference for the later research group to conduct the monitoring of plateau therapeutic drugs and the selection of research drugs.
作者
高子昭
王荣
赵安鹏
GAO Zizhao;WANG Rong;ZHAO Anpeng(College of Pharmacy,Ningxia Medical University,Yinchuan 730000,China;The PLA Plateau Medical Laboratory of No.940 Hospital of Joint Logistic Support Force,Lanzhou 730050,China)
出处
《药学实践杂志》
CAS
2020年第2期105-109,共5页
Journal of Pharmaceutical Practice
基金
国家科技重大专项(2018ZX09J18109-001)
国家自然科学基金(81403004,81401552,81673508)
全军后勤科研"十二五"重大项目(AWS14L0005)
全军医学科研"十二五"重点项目(BWS12J012)
甘肃省自然基金(145RJZA111)。
关键词
治疗药物监测
治疗窗
药物代谢
高原低氧
合理用药
therapeutic drug monitoring
therapeutic window
drug metabolism
plateau hypoxia
rational use
