摘要
目的:观察健脾理肺方联合鼻内镜与西药治疗真菌性鼻窦炎的效果。方法:纳入确诊为真菌性鼻窦炎的104例肺脾两虚证患者,按随机数字表法将患者分为2组各52例,2组均以鼻内镜治疗,术后以醋酸泼尼松片、丙酸氟替卡松吸入气雾剂连续治疗1个月。观察组加予健脾理肺方治疗,疗程为1个月。观察2组患者治疗前后鼻黏膜纤毛传输速率(MTR)、嗜酸性粒细胞计数、Th1/Th2细胞因子[γ-干扰素(IFN-γ)、白细胞介素-2 (IL-2)、白细胞介素-4 (IL-4)、白细胞介素-5 (IL-5)]的变化。比较2组的临床疗效。结果:治疗后,观察组临床疗效总有效率98.08%,高于对照组的78.85%(P<0.05)。2组MTR均较治疗前加快(P<0.05),观察组MTR快于对照组(P<0.05)。2组嗜酸性粒细胞计数值均较治疗前减少(P<0.05),观察组嗜酸性粒细胞计数值低于对照组(P<0.05)。2组IFN-γ、IL-2、IL-4、IL-5水平均较治疗前下降(P<0.05),观察组IFN-γ、IL-2、IL-4、IL-5水平均低于对照组(P<0.05)。结论:健脾理肺方联合鼻内镜与西药治疗真菌性鼻窦炎可以增强局部的免疫防御功能,具有良好的消炎镇痛作用。
Objective: To observe the effect of Jianpi Lifei prescription combined with nasal endoscope and western medicine on fungal sinusitis. Methods: A total of 104 cases of patients with confirmed diagnosis of fungal sinusitis with deficiency of lung and spleen syndrome were divided into two groups according to the random number table method,52 cases in each group. Both groups were given nasal endoscope,and after surgery,they were treated with prednisone acetate tablets and aerosol inhaling of fluticasone propionate continuously for one month. The observation group was additionally given Jianpi Lifei prescription for one month. Before and after treatment,the changes of nasal mucociliary transport rate(MTR),eosinophil counts,and levels of Th1/Th2 cytokines including interferon-γ(IFN-γ),interleukin-2(IL-2),interleukin-4(IL-4)and interleukin-5(IL-5) were observed in the two groups. The clinical effect in the two groups was compared. Results:After treatment,the total effective rate was 98.08% in the observation group,higher than that of 78.85% in the control group(P<0.05). MTR in the two groups was accelerated when compared with that before treatment(P<0.05), and MTR in the observation group was faster than that in the control group(P<0.05). The eosinophil counts in the two groups were decreased when compared with those before treatment(P<0.05),and the eosinophil count in the observation group was lower than that in the control group(P<0.05). The levels of IFN-γ,IL-2,IL-4 and IL-5 in the two groups were all decreased compared with those before treatment(P<0.05),and the above levels in the observation group were all lower than those in the control group(P<0.05). Conclusion: The therapy of Jianpi Lifei prescription combined with nasal endoscope and western medicine for fungal sinusitis can enhance the local immune defense function,which has good antiphlogistic and analgesic effect.
出处
《新中医》
CAS
2020年第4期96-98,共3页
New Chinese Medicine
关键词
真菌性鼻窦炎
肺脾两虚证
中西医结合疗法
健脾理肺方
鼻内镜
Th1/Th2细胞因子
鼻黏膜纤毛传输速率
嗜酸性粒细胞计数
Fungal sinusitis
Deficiency of lung and spleen syndrome
Integrated Chinese and western medicine therapy
Jianpi Lifei prescription
Nasal endoscope
Th1/Th2 cytokines
Nasal mucociliary transport rate
Eosinophil count
