摘要
目的:观察普萘洛尔联合马来酸噻吗洛尔治疗不同分型婴幼儿血管瘤(IH)的疗效差异。方法:将146例IH患儿根据瘤体侵及深度分为浅表组38例、深部组59例、混合组49例,所有患儿均接受口服普萘洛尔联合局部外用马来酸噻吗洛尔治疗6个月或病变完全消失。以治疗2、4、6个月为评定时间点,对比三组患儿病灶颜色、大小视觉模拟评分(VAS)和治疗6个月后临床疗效的差异,并记录不良反应。结果:所有患儿均完成治疗,用药时间4~6个月。治疗期间三组患儿病灶颜色及大小VAS评分均呈显著上升趋势(P<0.01),三组间比较差异有统计学意义(P<0.01),其中浅表组和混合组病灶颜色及大小改善程度优于深部组;治疗6个月后临床疗效三组间比较差异有统计学意义(P<0.05),其中浅表组最高为89.5%,深部组最低为64.4%;三组患儿治疗期间不良反应发生率为6.2%,三组间不良反应发生率比较差异无统计学意义(P>0.05)。结论:口服普萘洛尔联合局部外用马来酸噻吗洛尔治疗婴幼儿血管瘤安全有效,其中浅表型和混合型疗效优于深部型。
Objective:To observe the efficacy of oral propranolol combined with topical timolol maleate on different patterns of infantile hemangioma(IH).Methods:146 infants with IH were classified as superficial group(38 cases),deep group(59 cases) and mixed group(49 cases) according to the depth of tumor invasion.All infants were treated with oral propranolol combined with topical timolol maleate for 6 months or until the hemangioma completely regressed.The changes of lesion color and size visual analogue scale(VAS) in three groups were compared and analyzed at 2,4 and 6 months,and the therapeutic outcome after 6 months were compared between three groups.The adverse reactions of infants during treatment were recorded.Results:All the infants completed the treatment and the therapy duration was 4 to 6 months.The color and size VAS scores of the three groups showed a significant upward trend(P<0.01),and there were significant differences between the three groups(P<0.01).The improvement of color and size in superficial group and mixed group was better than that in deep group.There were statistical differences in therapeutic outcome between the three groups after 6 months(P<0.05).The highest clinical effective rate in superficial group was 89.5%,and the lowest in deep group was 64.4%.The incidence of adverse reactions during treatment in the three groups was 6.2%,and there was no statistical difference in the incidence of adverse reactions between the three groups(P>0.05).Conclusion:The treatment of oral opropranolol combined with topical timolol maleate for infantile hemangioma is effective and safe,and the curative effect of superficial and mixed hemangioma is better than that of deep hemangioma.
作者
李晓飞
陈峻江
LI Xiaofei;CHEN Junjiang(The Third Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000)
出处
《陕西医学杂志》
CAS
2020年第4期498-501,共4页
Shaanxi Medical Journal
