摘要
目的观察性激素结合球蛋白(SHBG)与女性绝经后骨密度的关系。方法回顾性分析南京中医药大学附属中西医结合医院内分泌科2017年1月至12月进行腰椎L1-4、股骨颈、全髋骨密度测定的165例绝经后女性患者为研究对象,用电化学发光法检测雌二醇、睾酮、SHBG等。结果各部位骨密度均与年龄呈负相关,与体质指数(BMI)、腰围呈正相关。雌二醇、睾酮与各部位骨密度无相关性,而SHBG与各部位骨密度均呈负相关(P≤0.001),校正年龄、BMI后,SHBG仍与全髋骨密度呈负相关(r=-0.187,P<0.05)。高SHBG组绝经后女性发生骨质疏松/骨量减少的风险高于低SHBG水平组(OR=3.115,P<0.01)。结论血清SHBG水平升高可能是绝经后女性骨密度下降的独立危险因素。
Objective To investigate the relationship between sex hormone binding globulin(SHBG)level and bone mineral density(BMD)in post-menopausal women.Methods Totally 165 post-menopausal women were enrolled from January to December in 2017,BMD in lumber 1-4,femoral neck and total hip was tested,estradiol(E2),testosterone(T)and SHBG were measured by electrochemical luminescence.Results BMD in each site was negatively related to age,while positively related to body mass index and waist.No relationship was found between E2、T and BMD,while SHBG was negatively correlated to BMD in each site(P≤0.001).After adjusting age,BMI,SHBG was still negatively related to BMD in total hip(r=-0.187,P<0.05).Postmenopausal women with high SHBG level carries higher risk of osteoporosis/osteopenia than that with low SHBG level(OR=3.115,P<0.01).Conclusion Elevated serum SHBG level may be an independent factor for decreased BMD in menopausal women.
作者
刘洲君
孙洪平
曹琳
胡咏新
LIU Zhoujun;SUN Hongping;CAO Lin;HU Yongxin(Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjanng,Jiangsu 210028,China;Jiangsu Province Academy of Traditional Chinese Medicine,Nanjanng,Jiangsu 210028,China)
出处
《大医生》
2019年第18期20-21,共2页
Doctor
关键词
性激素结合球蛋白
绝经
骨密度
sex hormone binding globulin
postmenopausal
bone mineral density
