摘要
目的了解包头市妊娠期妇女碘营养状况与甲状腺功能的关系,为指导孕妇科学补碘提供依据。方法选取2017年1月至2017年12月就诊于内蒙古包钢医院处于妊娠早、中、晚期的妇女各30例作为研究对象,采用砷铈催化法测定尿碘浓度,采用电化学发光免疫分析法测定甲状腺功能及抗体水平。结果妊娠早期碘缺乏者、碘适宜者、碘过多者分别占36.67%、40.00%、23.33%,妊娠中期分别为66.67%、26.67%、6.66%,妊娠晚期分别为40.00%、40.00%、20.00%。妊娠中期妇女的碘缺乏率显著高于妊娠早、晚期妇女,差异有显著性(P<0.05)。妊娠期妇女碘缺乏率与甲状腺过氧化物酶抗体阳性之间呈正相关,与甲状腺球蛋白抗体阳性无关。妊娠期碘缺乏及碘过多者的甲状腺功能及自身抗体异常率均明显高于碘适宜者,差异均有显著性(P<0.05)。结论妊娠中期妇女的缺碘情况比妊娠早、晚期妇女的缺碘情况严重;妊娠期碘缺乏与甲状腺过氧化物酶抗体阳性呈正相关;妊娠期碘缺乏及碘过多者甲状腺功能及自身抗体异常率高。建议对妊娠期妇女进行碘营养知识健康教育,开展妊娠期尿碘水平动态监测和甲状腺功能及抗体筛查。
Objective To investigate the iodine nutritional status and thyroid function of pregnant women in Bao Tou, and provide scientific basis for iodine supplementation. Method The urine iodine concentration and thyroid function were determined in 90 pregnant women during different periods in Baogang Hospital of inner Mongolia from January 2017 to December 2017. The detemination of urinary iodine concentration was carried out by arsenic cerium. The Thyroid function was determined by electrochemiluminescence immunoassay. Result In early pregnancy, Iodine deficiency iodine suitable, iodine excess accounted for 36.67%, 40.00%, 23.33% respectively, 66.67%, 26.67%, 6.66% in the middle of pregnancy, 40.00%, 40.00% and 20.00% respectively in the late pregnancy. The iodine deficiency rate of women in early pregnancy was significantly higher than that in the pregnant and late women, and the difference was statistically significant(P<0.05). There was no significant difference between the iodine deficiency in the women in the third trimester, and there was no statistical difference. Pregnancy women with thyroid iodine deficiency rate was positive correlation with antibody TPOAb positive, women iodine deficiency during pregnancy rate had nothing to do with the positive TgAb. Iodine deficiency of thyroid dysfunction and antibody positive during pregnancy rate was significantly higher than the iodine suitable rate of thyroid dysfunction, iodine overdose of thyroid dysfunction during pregnancy rate was significantly higher than the iodine suitable rate of thyroid dysfunction, statistically significant difference(P< 0.05). Conclusion The iodine deficiency of women in middle pregnancy was more serious than that of women in the early and late stages of pregnancy. Iodine deficiency during pregnancy was positive correlation with TPOAb thyroid antibody positive rate.Iodine deficiency in pregnancy and excessive iodine increased the abnormal rate of thyroid function and antibody positive. It was necessary to popularize iodine nutrition knowledge to pregnant women,and urinary iodine and thyroid function monitoring should be conducted in pregnant women.
作者
范媛媛
王雅璐
李宸辉
李子玲
FAN Yuan-yuan;WANG Ya-lu;LI Chen-hui;LI Zi-ling(Department of Endocrinology,Inner Mongolia Steel Hospital,Inner Mongolia Baotou 014010,China;Chinese People’s Liberation Army Naval Military Medical University,Shanghai 200433,China)
出处
《中国医刊》
CAS
2020年第4期379-382,共4页
Chinese Journal of Medicine
基金
内蒙古自治区自然科学基金(2016MS08120)。
关键词
碘营养状况
妊娠
尿碘
甲状腺功能
Iodine nutrition status
Pregnancy
Urinary iodine
Thyroid function
