摘要
目的观察三黄稳心汤治疗气虚痰浊、瘀毒互结证冠心病心绞痛冠状动脉介入术(PCI)后患者的临床疗效。方法选择2017年5月—2018年9月在重庆市中医院心血管病科因冠心病不稳定性心绞痛入院并接受PCI治疗,中医辨证为气虚痰浊、瘀毒互结的80例患者,将患者随机分为试验组40例和对照组40例。对照组仅给予西医基础治疗,试验组在西医治疗基础上给予三黄稳心汤口服,两组疗程均为1个月。治疗前后检测血清C-反应蛋白(CRP)、N末端前脑钠肽(NT-proBNP)和血脂水平,多普勒超声检测心脏功能,观察患者临床疗效和安全性指标。结果试验组脱落3例。与本组治疗前比较,两组治疗后NT-pro BNP、CRP、TC、TG、LDL-C水平下降(P<0.05),HDL-C水平、射血分数(EF)升高(P<0.05)。与对照组同期比较,试验组治疗后NT-pro BNP、TC、LDL-C水平及左室收缩末直径(LVESD)下降(P<0.05),临床有效率、HDL-C水平、EF升高(P<0.05)。两组均无不良反应发生,ALT、CR异常患者例数比较,差异无统计学意义(P>0.05)。结论三黄稳心汤联合西医基础治疗能够改善冠心病心绞痛PCI术后气虚痰浊、瘀毒互结证患者心功能,降低血脂水平。
Objective To observe the clinical effect of Sanhuang Wenxin Decoction(SHWXD) for qi deficiency, phlegm turbidity and blood stasis syndrome(QPBS) patients with coronary heart disease angina pectoris after percutaneous coronary intervention(PCI) by randomized controlled study. MethodTotally 80 QPBS hospitalized patients were included in the department of cardiovascular diseases, Chongqing hospital of traditional Chinese medicine from May, 2017 to September, 2018. All patients were diagnosed as coronary heart disease unstable angina pectoris and received PCI treatment. The patients were randomly divided into treatment group(40 cases) and control group(40 cases). Basic Western medicine was given in control group, SHWXD was additionally given in treatment group. The treatment course was 1 month. C-reactive protein(CRP), N-terminal pro-brain natriuretic peptide(NT-proBNP) and blood lipid level were detected before and after treatment. Doppler ultrasound was used to detect cardiac function. The clinical efficacy and indexes of safety were observed. Results Totally 3 cased were lost in treatment group. Compared with before treatment, the levels of NT-proBNP, CRP, TC, TG and LDL-C decreased(P<0.05), the levels of HDL-C and ejection fraction(EF) increased after treatment in both two groups(P<0.05).Compared with same time in control group, NT-proBNP, TC,LDL-C levels, left ventricular contraction endometriosis decreased(P<0.05), the effective rate, HDL-C level and EF increased after treatment in treatment group(P<0.05). There was no adverse reaction in both two groups. There was no statistics difference in the number of patients with abnormal ALT and CR between two groups(P>0.05).Conclusion SHWXD combined with basic Western medicine can improve the cardic function of QPBS patients with coronary heart disease unstable angina pectoris after PCI, and decreased the blood lipids level.
作者
柏哲
祝海毅
曹晋
罗玲
何德英
李勇
任毅
BAI Zhe;ZHU Hai-yi;CAO Jin;LUO Ling;HE De-ying;LI Yong;REN Yi(Department of Cardiovascular Diseases,Chongqing Hospital of Traditional Chinese Medicine,Chongqing(400021;Clinical Department of Integrated Chinese and Western Medicine,Guizhou University of Traditional Chinese Medicine,Guiyang(550002))
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2020年第3期290-294,共5页
Chinese Journal of Integrated Traditional and Western Medicine
基金
重庆市卫计委中医药科技项目(No.zy201603180)。
关键词
冠心病心绞痛
气虚痰浊、瘀毒互结证
三黄稳心汤
随机对照研究
coronary heart disease angina pectoris
qi deficiency,phlegm turbidity and blood stasis syndrome
Sanhuang Wenxin Decoction
randomized controlled study
