摘要
结直肠癌(colorectal cancer,CRC)是世界范围内较为高发的恶性肿瘤,近几年,我国的CRC发病率明显升高。大量研究表明微生物在CRC发生发展中发挥重要作用。具核梭杆菌(Fusobacteriumnucleatum,FN)是一种口腔中常见的革兰阴性菌,常累及牙周疾病。但越来越多的研究发现,在CRC组织中,FN的感染率增加,且FN感染与CRC的发生发展有关。因此,本文对FN与CRC的相关研究进展进行综述,以期为CRC的早期诊断、高危人群的识别和治疗提供新的视角。
Colorectal cancer( CRC) is a malignant tumor that has a relatively high incidence aroud the world. In recent years,the incidence of CRC has increased significantly in China. Studies have shown that microorganisms play an important role in the progression of CRC. Fusobacteriumnucleatum( FN) is a gram-negative bacterium commonly found in the oral cavity and is often involved in periodontal diseases. Numerous studies have found that the infection rate of FN increases in CRC tissues,and FN infection is related to the occurrence and development of CRC. Therefore,this paper reviews the research progress on the relationship between FN and CRC,in order to provide a new perspective for the early diagnosis of CRC,the identification and treatment of high-risk populations.
作者
郭术楠
汪庚明
GUO Shunan;WANG Gengming(Bengbu Medical College,Bengbu 233000,China;Department of Radiation Oncology,The First Affiliated Hospital of Bengbu Medical College)
出处
《沈阳医学院学报》
2020年第2期165-169,共5页
Journal of Shenyang Medical College
基金
安徽省十三五临床医学优先发展重点专科(卫科教2018-291)。
关键词
结直肠癌
具核梭杆菌
诊断
治疗
colorectal cancer
Fusobacteriumnucleatum
diagnosis
therapy
