摘要
以罗丹明B和乙二胺为原料,通过缩合反应制得罗丹明酰乙二胺(1, Rhb);然后以无水THF作溶剂,化合物1与三聚氯嗪发生亲核取代反应,得到罗丹明酰乙二胺-三聚氯嗪化合物(2, Rhbc);最后在氮气氛围下,化合物2与N,N-二甲基吡啶胺反应合成了目标产物双(2-吡啶苄基)胺罗丹明基小分子探针(3, Rhbd),其结构经1H NMR、IR、 HR-MS和元素分析表征。该探针可以识别Fe3+,检出限为30 nM。
Rhodamine B and ethylenediamine are used as raw materials to prepare rhodamine ethdiamine(1,Rhb) by condensation reaction. Then, using anhydrous THF as a solvent, the nucleophilic substitution reaction of the compound 1 and the cyanuric chloride gives the rhodamine ethoxydiamine-trichloro azine compound(2, Rhbc). Finally, under the N2 atmosphere, the reaction of compound 1 and N,N-dimethylpyridinium to get the target product bis(2-pyridylbenzyl) amine rhodamine-based small molecule probe(3, Rhbd), and its structure was charactized to 1H NMR, IR, HR-MS and elemental analysis. The probe can recognize Fe3+ and the detection limit is 3 nM.
作者
易春雪
赵岗
光善仪
徐洪耀
YI Chun-xue;ZHAO Gang;GUANG Shan-yi;XU Hong-yao(College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China;College of Materials Sciences and Engineering,Donghua University,Shanghai 201620,China)
出处
《合成化学》
CAS
北大核心
2020年第3期229-233,共5页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(21671037,21471030)。
关键词
罗丹明B
乙二胺
三聚氯嗪
N
N-二甲基吡啶胺
合成
Rhodamine B
ethylenediamine
cyanuric chloride
N,N-dimethylpyridinium
synthesis
