摘要
目的:观察自拟宣肺固卫协定Ⅰ号方联合盐酸纳洛酮注射液改善慢性肺心病呼吸衰竭患者心肺功能的临床效果,分析其对外周血白细胞介素-9(IL-9)、D-二聚体、血管性血友病因子(vWF)、内皮素-1(ET-1)水平的影响。方法:选取2017年1月-2019年1月本院收治的慢性肺心病呼吸衰竭患者82例。按照随机数字表法将其分为对照组和观察组,各41例。对照组予以盐酸纳洛酮注射液治疗,观察组在对照组基础上予以自拟宣肺固卫协定Ⅰ号方治疗。比较两组临床效果、症状缓解时间、心肺功能及血清IL-9、D-二聚体、vWF、ET-1水平。结果:观察组总有效率92.68%,显著高于对照组的73.17%(P<0.05);经治疗,观察组气促、咳嗽、肺啰音、心悸的缓解时间均较对照组明显缩短,差异均有统计学意义(P<0.05);治疗后,观察组RVEDD、PASP、cTnI水平均低于对照组,RVEF水平高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组FVC、FEV1、PaO2均高于对照组,PaCO2水平低于对照组,差异均有统计学意义(P<0.05);治疗后,观察组外周血IL-9、D-二聚体、vWF、ET-1水平均低于对照组,差异均有统计学意义(P<0.05);观察组、对照组的不良反应发生率分别为4.88%、7.32%,比较差异无统计学意义(P>0.05)。结论:自拟宣肺固卫协定Ⅰ号方联合盐酸纳洛酮注射液利于促进慢性肺心病呼吸衰竭患者临床症状的缓解,改善心肺功能、血气指标、体内纤溶状态,抑制炎性反应,保护内皮功能,具有较高的用药安全性。
Objective:To observe the clinical effect of Self-designed Xuanfei GuweiⅠDecoction combined with Naloxone Hydrochloride Injection on the improvement of cardiopulmonary function in patients with chronic pulmonary heart disease and respiratory failure,and to analyze the influence of its levels of interleukin-9(IL-9),D-dimer,von Willebrand factor(VWF),endothelin-1(ET-1)in peripheral blood.Method:From January 2017 to January 2019,82 patients with chronic pulmonary heart disease and respiratory failure in our hospital were selected.According to the method of random number table,they were divided into control group and observation group,41 cases in each group.The control group was treated with Naloxone Hydrochloride Injection,and the observation group was treated with Self-designed Xuanfei GuweiⅠDecoction.The clinical effect,symptom relief time,cardiopulmonary function and serum levels of IL-9,D-dimer,vWF and ET-1 were compared between the two groups.Result:The total effective rate of the observation group was 92.68%,which was significantly higher than 73.17%of the control group(P<0.05).After treatment,the relieving time of dyspnea,cough,rale and palpitation in the observation group were significantly shorter than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of RVEDD,PASP and cTnI in the observation group were lower than those in the control group,and the levels of RVEF was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,FVC,FEV1 and PaO2 in the observation group were higher than those in the control group,and PaCO2 level was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of IL-9,D-dimer,vWF and ET-1 in peripheral blood of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group and control group were 4.88%and 7.32%respectively,with no significant difference(P>0.05).Conclusion:The Self-designed Xuanfei GuweiⅠDecoction combined with Naloxone Hydrochloride Injection can promote the relief of clinical symptoms,improve the cardiopulmonary function,blood gas index,fibrinolytic state in vivo,inhibit inflammatory reaction,protect endothelial function,and have high drug safety.
作者
周远军
杨道阔
ZHOU Yuanjun;YANG Daokuo(People’s Hospital of Shashi District,Jingzhou 434000,China;不详)
出处
《中国医学创新》
CAS
2020年第3期73-78,共6页
Medical Innovation of China
